Tubulin/HDAC-IN-2
Tubulin/HDAC-IN-2 (Compound II-19k) is a dual inhibitor of Tubulin and HDAC, with an IC50 of 0.403 μM, 0.591μM, 3.552μM, 0.459μM for HDAC1/2/3/6. Tubulin/HDAC-IN-2 blocks cell cycle arrest at G2 phase, induces cell apoptosis. Tubulin/HDAC-IN-2 inhibits the growth of hematoma and solid tumor cells, reduces tumor metastasis, and also inhibits tumor growth in a liver tumor allograft mouse model.
For research use only. We do not sell to patients.
- CAS No.: 3049740-77-1
- Formula: C21H19FN2O4
- Molecular Weight:382.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
0.005 μM
Compound: II-19k
|
Antiproliferative activity against human A2780 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human A2780 cells incubated for 72 hrs by MTT assay
|
[PMID: 37269670] |
| A549 | IC50 |
0.017 μM
Compound: II-19k
|
Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay
|
[PMID: 37269670] |
| B16-F10 | IC50 |
0.005 μM
Compound: II-19k
|
Antiproliferative activity against mouse B16-F10 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against mouse B16-F10 cells incubated for 72 hrs by MTT assay
|
[PMID: 37269670] |
| H22 | IC50 |
0.008 μM
Compound: II-19k
|
Antiproliferative activity against mouse H22 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against mouse H22 cells incubated for 72 hrs by MTT assay
|
[PMID: 37269670] |
| HFL1 | IC50 |
0.23 μM
Compound: II-19k
|
Antiproliferative activity against human HFL1 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human HFL1 cells incubated for 72 hrs by MTT assay
|
[PMID: 37269670] |
| HUVEC | IC50 |
0.192 μM
Compound: II-19k
|
Inhibition of tube formation in HUVEC cells incubated for 24 hrs by inverted microscopy
Inhibition of tube formation in HUVEC cells incubated for 24 hrs by inverted microscopy
|
[PMID: 37269670] |
| K562 | IC50 |
0.003 μM
Compound: II-19k
|
Antiproliferative activity against human K562 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human K562 cells incubated for 72 hrs by MTT assay
|
[PMID: 37269670] |
| MCF7 | IC50 |
0.036 μM
Compound: II-19k
|
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay
|
[PMID: 37269670] |
| MDA-MB-231 | IC50 |
0.011 μM
Compound: II-19k
|
Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay
|
[PMID: 37269670] |
Chemical Information
-
CAS No. 3049740-77-1
-
Molecular Weight 382.38
-
Formula C21H19FN2O4
-
SMILES
O=C(NO)C(F)OC1=CC(C(C2=CC(C)=NC3=CC=CC=C23)=C)=CC=C1OC
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)