2. Cell Cycle/DNA Damage Apoptosis Epigenetics Cytoskeleton
  3. Microtubule/Tubulin HDAC Apoptosis
  4. Tubulin/HDAC-IN-2

Tubulin/HDAC-IN-2 (Compound II-19k) is a dual inhibitor of Tubulin and HDAC, with an IC50 of 0.403 μM, 0.591μM, 3.552μM, 0.459μM for HDAC1/2/3/6. Tubulin/HDAC-IN-2 blocks cell cycle arrest at G2 phase, induces cell apoptosis. Tubulin/HDAC-IN-2 inhibits the growth of hematoma and solid tumor cells, reduces tumor metastasis, and also inhibits tumor growth in a liver tumor allograft mouse model.

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Tubulin/HDAC-IN-2

Tubulin/HDAC-IN-2 Estructura química

No. CAS : 3049740-77-1

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Tubulin/HDAC-IN-2 Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Descripciòn

Tubulin/HDAC-IN-2 (Compound II-19k) is a dual inhibitor of Tubulin and HDAC, with an IC50 of 0.403 μM, 0.591μM, 3.552μM, 0.459μM for HDAC1/2/3/6. Tubulin/HDAC-IN-2 blocks cell cycle arrest at G2 phase, induces cell apoptosis. Tubulin/HDAC-IN-2 inhibits the growth of hematoma and solid tumor cells, reduces tumor metastasis, and also inhibits tumor growth in a liver tumor allograft mouse model[1].

Cellular Effect
Cell Line Type Value Description References
A2780 IC50
0.005 μM
Compound: II-19k
Antiproliferative activity against human A2780 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human A2780 cells incubated for 72 hrs by MTT assay
[PMID: 37269670]
A549 IC50
0.017 μM
Compound: II-19k
Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay
[PMID: 37269670]
B16-F10 IC50
0.005 μM
Compound: II-19k
Antiproliferative activity against mouse B16-F10 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against mouse B16-F10 cells incubated for 72 hrs by MTT assay
[PMID: 37269670]
H22 IC50
0.008 μM
Compound: II-19k
Antiproliferative activity against mouse H22 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against mouse H22 cells incubated for 72 hrs by MTT assay
[PMID: 37269670]
HFL1 IC50
0.23 μM
Compound: II-19k
Antiproliferative activity against human HFL1 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human HFL1 cells incubated for 72 hrs by MTT assay
[PMID: 37269670]
HUVEC IC50
0.192 μM
Compound: II-19k
Inhibition of tube formation in HUVEC cells incubated for 24 hrs by inverted microscopy
Inhibition of tube formation in HUVEC cells incubated for 24 hrs by inverted microscopy
[PMID: 37269670]
K562 IC50
0.003 μM
Compound: II-19k
Antiproliferative activity against human K562 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human K562 cells incubated for 72 hrs by MTT assay
[PMID: 37269670]
MCF7 IC50
0.036 μM
Compound: II-19k
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay
[PMID: 37269670]
MDA-MB-231 IC50
0.011 μM
Compound: II-19k
Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay
[PMID: 37269670]
Peso molecular

382.38

Fòrmula

C21H19FN2O4
No. CAS
SMILES

O=C(NO)C(F)OC1=CC(C(C2=CC(C)=NC3=CC=CC=C23)=C)=CC=C1OC
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
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Tubulin/HDAC-IN-2 Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin/HDAC-IN-23049740-77-1Microtubule/TubulinHDACApoptosisHistone deacetylasesTumorhematomaliverK562tumor metastasisInhibitorinhibitorinhibit

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Tubulin/HDAC-IN-2
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HY-155523
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