TrxR1-IN-B19
TrxR1-IN-B19 (GO-Y015) (Compound B19) is a Curcumin (HY-N0005) derivative and colvalent TrxR1 inhibitor. TrxR1-IN-B19 inhibits TrxR1 enzyme activity to elevate oxidative stress, and then induce ROS-mediated ER Stress and mitochondrial dysfunction, subsequently resulting in cell cycle arrest and apoptosis.
For research use only. We do not sell to patients.
- CAS No.: 170950-29-5
- Formula: C21H22O5
- Molecular Weight:354.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| BGC-823 | IC50 |
24.4 μM
Compound: B4
|
Cytotoxicity against human BGC823 cells after 72 hrs by MTT assay
Cytotoxicity against human BGC823 cells after 72 hrs by MTT assay
|
[PMID: 19243951] |
| HCT-116 | GI50 |
1.3 μM
Compound: GO-Y015
|
Growth inhibition of human HCT116 cells after 48 hrs by MTS assay
Growth inhibition of human HCT116 cells after 48 hrs by MTS assay
|
[PMID: 20060305] |
| HL-60 | IC50 |
24.3 μM
Compound: B4
|
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
|
[PMID: 19243951] |
| KB | IC50 |
4.5 μM
Compound: B4
|
Cytotoxicity against human KB cells after 72 hrs by MTT assay
Cytotoxicity against human KB cells after 72 hrs by MTT assay
|
[PMID: 19243951] |
| LS174T | IC50 |
48 μM
Compound: B4
|
Cytotoxicity against human LS 174T cells after 72 hrs by MTT assay
Cytotoxicity against human LS 174T cells after 72 hrs by MTT assay
|
[PMID: 19243951] |
| NCI-H460 | IC50 |
6.74 μM
Compound: 19
|
Cytotoxicity against human NCI-H460 cells after 72 hrs by MTT assay
Cytotoxicity against human NCI-H460 cells after 72 hrs by MTT assay
|
[PMID: 21504179] |
Chemical Information
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CAS No. 170950-29-5
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Molecular Weight 354.40
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Formula C21H22O5
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SMILES
COC(C(OC)=CC=C1)=C1/C=C/C(/C=C/C2=C(C(OC)=CC=C2)OC)=O
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Synonyms
GO-Y015
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)