170950-29-5
170950-29-5
Chemical Structure
TrxR1-IN-B19
Synonym(s): GO-Y015
- CAS No.: 170950-29-5
- Formula:C21H22O5
- Molecular Weight:354.40
IUPAC Name: (1E,4E)-1,5-bis(2,3-dimethoxyphenyl)penta-1,4-dien-3-one
InChIKey: LSNRKPCFLXRJGN-PHEQNACWSA-N
SMILES: COC(C(OC)=CC=C1)=C1/C=C/C(/C=C/C2=C(C(OC)=CC=C2)OC)=O
Biological Activity: TrxR1-IN-B19 (GO-Y015) (Compound B19) is a Curcumin (HY-N0005) derivative and colvalent TrxR1 inhibitor. TrxR1-IN-B19 inhibits TrxR1 enzyme activity to elevate oxidative stress, and then induce ROS-mediated ER Stress and mitochondrial dysfunction, subsequently resulting in cell cycle arrest and apoptosis[1].
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TrxR1-IN-B19 | TrxR1-IN-B19 (GO-Y015) (Compound B19) is a Curcumin (HY-N0005) derivative and colvalent TrxR1 inhibitor. TrxR1-IN-B19 inhibits TrxR1 enzyme activity to elevate oxidative stress, and then induce ROS-mediated ER Stress and mitochondrial dysfunction, subsequently resulting in cell cycle arrest and apoptosis. | |||||||||||||||||||||
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