1. Protein Tyrosine Kinase/RTK
    JAK/STAT Signaling
  2. EGFR
  3. Cyasterone

Cyasterone 

Cat. No.: HY-N0211
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Cyasterone, a natural EGFR inhibitor, mainly isolated from Ajuga decumbens Thunb (Labiatae). Cyasterone manifests anti-proliferation effect by induced apoptosis and cell cycle arrests. Cyasterone may serves as a therapeutic anti-tumor agent against human tumors.

For research use only. We do not sell to patients.

Cyasterone Chemical Structure

Cyasterone Chemical Structure

CAS No. : 17086-76-9

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Description

Cyasterone, a natural EGFR inhibitor, mainly isolated from Ajuga decumbens Thunb (Labiatae). Cyasterone manifests anti-proliferation effect by induced apoptosis and cell cycle arrests. Cyasterone may serves as a therapeutic anti-tumor agent against human tumors[1].

IC50 & Target

IC50: EGFR[1]

In Vitro

Cyasterone exerts cytotoxicity on multiple cell lines: HeLa (IC50=77.24 μg/ml); HepG-2 (IC50=52.03 μg/ml); MCF-7 (IC50=82.07 μg/ml) and MCF-7 (IC50=82.07 μg/ml). And It has none cytotoxicity (IC50>400 μg/ml) on 3 types of carcinoma (HT-29, Caco-2, T47D) and 1 type of normal (NIH 3T3) cell lines[1].
Cyasterone (0-60 μg/ml; 48 hours) causes a significantly decreasing of the cell proliferation. It inhibits cell growth as a dose-dependent manner, exhibits IC50 values of 38.50 μg/ml and 32.96 μg/ml, respectively[1].
Cyasterone (0-60 μg/ml; 24 hours) decreases p-EGFR, p-MEK, and p-mTOR as a dose-dependent manner in A549 cells, it affects the MAPK signaling pathway activities[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: A549 cells and MGC823 cells
Concentration: 0 μg/ml, 20 μg/ml, 40 μg/ml, 60 μg/ml
Incubation Time: 24 hours
Result: Inhibited cell proliferation as a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: A549 cells
Concentration: 0 μg/ml, 20 μg/ml, 40 μg/ml, 60 μg/ml
Incubation Time: 24 hours
Result: Surpressed p-EGFR, p-MEK, and p-mTOR expression.
In Vivo

Cyasterone (intraperitoneal injection; 5 mg/kg, 10 mg/kg and 15 mg/kg; 21 days) has anti-proliferation effect in vivo and inhibits MGC823 cells xenografted tumor growth in vivo with few changes in body weights[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MGC823 xenograft tumor in BALB/C-nu mice[1]
Dosage: 5 mg/kg, 10 mg/kg and 15 mg/kg
Administration: Intraperitoneal injection
Result: Inhibited MGC823 xenograft tumor growth in vivo.
Molecular Weight

520.65

Formula

C₂₉H₄₄O₈

CAS No.

17086-76-9

SMILES
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Keywords:

CyasteroneEGFREpidermal growth factor receptorErbB-1HER1CANCERA549MGC823APOPTOSISInhibitorinhibitorinhibit

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