1. Apoptosis
  2. Apoptosis
  3. (Rac)-CCT 250863

(Rac)-CCT 250863 (compound rac-21) is a selective and reversible NEK 2 inhibitor with an IC50 of 0.073 µM. (Rac)-CCT 250863 shows good effects of inducing cell cycle arrest and also can antiproliferative in cells (Pomalidomide sensitive/resistant). (Rac)-CCT 250863 induces apoptosis when combines with Pomalidomide.

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(Rac)-CCT 250863 Chemical Structure

(Rac)-CCT 250863 Chemical Structure

CAS No. : 1364269-06-6

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Based on 1 publication(s) in Google Scholar

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Description

(Rac)-CCT 250863 (compound rac-21) is a selective and reversible NEK 2 inhibitor with an IC50 of 0.073 µM. (Rac)-CCT 250863 shows good effects of inducing cell cycle arrest and also can antiproliferative in cells (Pomalidomide sensitive/resistant). (Rac)-CCT 250863 induces apoptosis when combines with Pomalidomide[1][2].

IC50 & Target

IC50: 0.073 µM (NEK 2), 8.0 μΜ (H929), 7.1 μΜ (AMOl), 8.7 μΜ (K12PE)[1][2].

Molecular Weight

490.54

Formula

C24H25F3N4O2S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N)C1=CC=C(C2=CC(C3=CC(CN(C)C)=CS3)=CN=C2N)C=C1OC(C)/C=C\C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (101.93 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0386 mL 10.1928 mL 20.3857 mL
5 mM 0.4077 mL 2.0386 mL 4.0771 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.50%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0386 mL 10.1928 mL 20.3857 mL 50.9642 mL
5 mM 0.4077 mL 2.0386 mL 4.0771 mL 10.1928 mL
10 mM 0.2039 mL 1.0193 mL 2.0386 mL 5.0964 mL
15 mM 0.1359 mL 0.6795 mL 1.3590 mL 3.3976 mL
20 mM 0.1019 mL 0.5096 mL 1.0193 mL 2.5482 mL
25 mM 0.0815 mL 0.4077 mL 0.8154 mL 2.0386 mL
30 mM 0.0680 mL 0.3398 mL 0.6795 mL 1.6988 mL
40 mM 0.0510 mL 0.2548 mL 0.5096 mL 1.2741 mL
50 mM 0.0408 mL 0.2039 mL 0.4077 mL 1.0193 mL
60 mM 0.0340 mL 0.1699 mL 0.3398 mL 0.8494 mL
80 mM 0.0255 mL 0.1274 mL 0.2548 mL 0.6371 mL
100 mM 0.0204 mL 0.1019 mL 0.2039 mL 0.5096 mL
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(Rac)-CCT 250863 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
(Rac)-CCT 250863
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HY-117884
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