1364269-06-6
Chemical Structure
(Rac)-CCT 250863
- CAS No.: 1364269-06-6
- Formula:C24H25F3N4O2S
- Molecular Weight:490.54
IUPAC Name: (Z)-4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-((5,5,5-trifluoropent-3-en-2-yl)oxy)benzamide
InChIKey: LLEOOSLUHRQCHZ-SREVYHEPSA-N
SMILES: O=C(N)C1=CC=C(C2=CC(C3=CC(CN(C)C)=CS3)=CN=C2N)C=C1OC(C)/C=C\C(F)(F)F
Biological Activity: (Rac)-CCT 250863 (compound rac-21) is a selective and reversible NEK 2 inhibitor with an IC50 of 0.073 µM. (Rac)-CCT 250863 shows good effects of inducing cell cycle arrest and also can antiproliferative in cells (Pomalidomide sensitive/resistant). (Rac)-CCT 250863 induces apoptosis when combines with Pomalidomide[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(Rac)-CCT 250863 | 99.50% | (Rac)-CCT 250863 (compound rac-21) is a selective and reversible NEK 2 inhibitor with an IC50 of 0.073 µM. (Rac)-CCT 250863 shows good effects of inducing cell cycle arrest and also can antiproliferative in cells (Pomalidomide sensitive/resistant). (Rac)-CCT 250863 induces apoptosis when combines with Pomalidomide. | ||||||||||||||||||||
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- [1]. Innocenti P, et al. Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: structure-activity relationship, structural biology, and cellular activity. J Med Chem. 2012 Apr 12;55(7):3228-41.
- [2]. Ahsan A, et al. Methods for treating cancer with combination therapies. WO2021262962A1.
Keywords
