2. Others Apoptosis Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. Biochemical Assay Reagents Apoptosis DNA Alkylator/Crosslinker Lipoxygenase
  4. Triphenylphosphinechlorogold

Triphenylphosphinechlorogold  (Synonyms: Chloro(triphenylphosphine)gold(I))

Cat. No.: HY-W020955 Purity: 98%
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Triphenylphosphinechlorogold (Chloro(triphenylphosphine)gold(I)) is a gold complex, Apoptosis inducer, and catalyst. Triphenylphosphinechlorogold exhibits high LOX inhibitory activity. Triphenylphosphinechlorogold induces cell cycle arrest and apoptosis. Triphenylphosphinechlorogold catalyzes the peroxidation of linoleic acid. A weak interaction exists between Triphenylphosphinechlorogold and DNA. Triphenylphosphinechlorogold displays antiproliferative activity against breast cancer cells.

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Triphenylphosphinechlorogold

Triphenylphosphinechlorogold Chemical Structure

CAS No. : 14243-64-2

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Based on 1 publication(s) in Google Scholar

Triphenylphosphinechlorogold Related Antibodies

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Description

Triphenylphosphinechlorogold (Chloro(triphenylphosphine)gold(I)) is a gold complex, Apoptosis inducer, and catalyst. Triphenylphosphinechlorogold exhibits high LOX inhibitory activity. Triphenylphosphinechlorogold induces cell cycle arrest and apoptosis. Triphenylphosphinechlorogold catalyzes the peroxidation of linoleic acid. A weak interaction exists between Triphenylphosphinechlorogold and DNA. Triphenylphosphinechlorogold displays antiproliferative activity against breast cancer cells[1].

In Vitro

Triphenylphosphinechlorogold (48 h) potently inhibits the proliferation of breast cancer cell line MCF-7, with an IC50 of 3.8 μM; meanwhile, it exhibits toxicity similar to that of cisplatin against normal embryonic lung fibroblast cell line MRC-5, with an IC50 of 1.3 μM[1].
Triphenylphosphinechlorogold (48 h) exerts low genotoxicity on human normal fetal lung fibroblast MRC-5, with a micronucleus rate of 1.9% when the cells are treated at the IC50 concentration for 48 h[1].
Triphenylphosphinechlorogold (3.8 μM; 48 h) induces morphological changes characteristic of apoptosis in the human breast cancer cell line MCF-7 when treated at its IC50 concentration of 3.8 μM for 48 h[1].
Triphenylphosphinechlorogold (3.8 μM; 48 h) induces S-phase and G2/M-phase cell cycle arrest in breast adenocarcinoma MCF-7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Triphenylphosphinechlorogold Related Antibodies

Cell Proliferation Assay[1]

Cell Line: human breast adenocarcinoma MCF-7 cells, normal human fetal lung fibroblast MRC-5 cells
Concentration: multiple concentrations
Incubation Time: 48 h
Result: Exhibited an IC50 of 3.8 μM against MCF-7 cells, which was 1.5-fold stronger than cisplatin and 3-fold stronger than auranofin.
Had an IC50 of 1.3 μM against MRC-5 cells, similar to cisplatin.
Calculated a therapeutic potency index (TPI) of 0.3, similar to cisplatin's TPI of 0.2.

Apoptosis Analysis[1]

Cell Line: human breast adenocarcinoma MCF-7 cells
Concentration: 3.8 μM
Incubation Time: 48 h
Result: Induced shrunken, rounded cell morphology, loss of cell contact, and detachment from the plate, characteristic of apoptotic cell death, while control and DMSO-treated cells showed normal morphology.

Cell Cycle Analysis[1]

Cell Line: human breast adenocarcinoma MCF-7 cells
Concentration: 3.8 μM
Incubation Time: 48 h
Result: Increased the percentage of apoptotic cells in the sub-G1 phase from 1.8% in untreated cells to 4.3% in treated cells.
Increased the percentage of cells in the S phase from 10.4% to 11.9%, and the percentage in the G2/M phase from 31.9% to 33.1%, indicating cell cycle arrest at S and G2/M phases.

Apoptosis Analysis[1]

Cell Line: human breast adenocarcinoma MCF-7 cells
Concentration: 3.8 μM (IC50); 38 μM (10× IC50)
Incubation Time: 48 h
Result: Resulted in a total percentage of apoptotic cells (early + late) of 23% at 3.8 μM, compared to 4.6% in untreated cells.
Increased the total apoptotic cell percentage to 62.7% at 38 μM.
Molecular Weight

494.71

Formula

C18H15AuClP
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

Cl[Au][P](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (50.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0214 mL 10.1069 mL 20.2139 mL
5 mM 0.4043 mL 2.0214 mL 4.0428 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Purity: 99.93%

SDS (394 KB)

COA (253 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0214 mL 10.1069 mL 20.2139 mL 50.5347 mL
5 mM 0.4043 mL 2.0214 mL 4.0428 mL 10.1069 mL
10 mM 0.2021 mL 1.0107 mL 2.0214 mL 5.0535 mL
15 mM 0.1348 mL 0.6738 mL 1.3476 mL 3.3690 mL
20 mM 0.1011 mL 0.5053 mL 1.0107 mL 2.5267 mL
25 mM 0.0809 mL 0.4043 mL 0.8086 mL 2.0214 mL
30 mM 0.0674 mL 0.3369 mL 0.6738 mL 1.6845 mL
40 mM 0.0505 mL 0.2527 mL 0.5053 mL 1.2634 mL
50 mM 0.0404 mL 0.2021 mL 0.4043 mL 1.0107 mL
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Triphenylphosphinechlorogold Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Triphenylphosphinechlorogold14243-64-2Chloro(triphenylphosphine)gold(I)Biochemical Assay ReagentsApoptosisDNA Alkylator/CrosslinkerLipoxygenaseLOXlipoxygenaseMCF-7 human breast adenocarcinoma cellscalf thymus DNAbreast adenocarcinomaapoptosisleukotrienesmitochondriacell cycleMRC-5 normal human fetal lung fibroblast cellsglutathioneInhibitorinhibitorinhibit

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