Triphenylphosphinechlorogold
Based on 1 Customer Validation
Triphenylphosphinechlorogold (Chloro(triphenylphosphine)gold(I)) is a gold complex, Apoptosis inducer, and catalyst. Triphenylphosphinechlorogold exhibits high LOX inhibitory activity. Triphenylphosphinechlorogold induces cell cycle arrest and apoptosis. Triphenylphosphinechlorogold catalyzes the peroxidation of linoleic acid. A weak interaction exists between Triphenylphosphinechlorogold and DNA. Triphenylphosphinechlorogold displays antiproliferative activity against breast cancer cells.
For research use only. We do not sell to patients.
- Purity: 98%
- CAS No.: 14243-64-2
- Formula: C18H15AuClP
- Molecular Weight:494.71
-
Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Triphenylphosphinechlorogold (48 h) potently inhibits the proliferation of breast cancer cell line MCF-7, with an IC50 of 3.8 μM; meanwhile, it exhibits toxicity similar to that of cisplatin against normal embryonic lung fibroblast cell line MRC-5, with an IC50 of 1.3 μM[1].
Triphenylphosphinechlorogold (48 h) exerts low genotoxicity on human normal fetal lung fibroblast MRC-5, with a micronucleus rate of 1.9% when the cells are treated at the IC50 concentration for 48 h[1].
Triphenylphosphinechlorogold (3.8 μM; 48 h) induces morphological changes characteristic of apoptosis in the human breast cancer cell line MCF-7 when treated at its IC50 concentration of 3.8 μM for 48 h[1].
Triphenylphosphinechlorogold (3.8 μM; 48 h) induces S-phase and G2/M-phase cell cycle arrest in breast adenocarcinoma MCF-7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:human breast adenocarcinoma MCF-7 cells, normal human fetal lung fibroblast MRC-5 cells
-
Concentration:multiple concentrations
-
Incubation Time:48 h
-
Result:Exhibited an IC50 of 3.8 μM against MCF-7 cells, which was 1.5-fold stronger than cisplatin and 3-fold stronger than auranofin.
Had an IC50 of 1.3 μM against MRC-5 cells, similar to cisplatin.
Calculated a therapeutic potency index (TPI) of 0.3, similar to cisplatin's TPI of 0.2.
-
Cell Line:human breast adenocarcinoma MCF-7 cells
-
Concentration:3.8 μM
-
Incubation Time:48 h
-
Result:Induced shrunken, rounded cell morphology, loss of cell contact, and detachment from the plate, characteristic of apoptotic cell death, while control and DMSO-treated cells showed normal morphology.
-
Cell Line:human breast adenocarcinoma MCF-7 cells
-
Concentration:3.8 μM
-
Incubation Time:48 h
-
Result:Increased the percentage of apoptotic cells in the sub-G1 phase from 1.8% in untreated cells to 4.3% in treated cells.
Increased the percentage of cells in the S phase from 10.4% to 11.9%, and the percentage in the G2/M phase from 31.9% to 33.1%, indicating cell cycle arrest at S and G2/M phases.
-
Cell Line:human breast adenocarcinoma MCF-7 cells
-
Concentration:3.8 μM (IC50); 38 μM (10× IC50)
-
Incubation Time:48 h
-
Result:Resulted in a total percentage of apoptotic cells (early + late) of 23% at 3.8 μM, compared to 4.6% in untreated cells.
Increased the total apoptotic cell percentage to 62.7% at 38 μM.
Chemical Information
-
CAS No. 14243-64-2
-
Appearance Solid
-
Molecular Weight 494.71
-
Formula C18H15AuClP
-
Color White to off-white
-
SMILES
Cl[Au][P](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3
-
Synonyms
Chloro(triphenylphosphine)gold(I)
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 25 mg/mL (50.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (281 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0214 mL | 10.1069 mL | 20.2139 mL | 50.5347 mL |
| 5 mM | 0.4043 mL | 2.0214 mL | 4.0428 mL | 10.1069 mL | |
| 10 mM | 0.2021 mL | 1.0107 mL | 2.0214 mL | 5.0535 mL | |
| 15 mM | 0.1348 mL | 0.6738 mL | 1.3476 mL | 3.3690 mL | |
| 20 mM | 0.1011 mL | 0.5053 mL | 1.0107 mL | 2.5267 mL | |
| 25 mM | 0.0809 mL | 0.4043 mL | 0.8086 mL | 2.0214 mL | |
| 30 mM | 0.0674 mL | 0.3369 mL | 0.6738 mL | 1.6845 mL | |
| 40 mM | 0.0505 mL | 0.2527 mL | 0.5053 mL | 1.2634 mL | |
| 50 mM | 0.0404 mL | 0.2021 mL | 0.4043 mL | 1.0107 mL |
Triphenylphosphinechlorogold Related Classifications
HY-W020955 Related Classifications
Powered by Bioz
- Triphenylphosphinechlorogold
- 14243-64-2
- Chloro(triphenylphosphine)gold(I)
- Biochemical Assay Reagents
- Apoptosis
- DNA Alkylator/Crosslinker
- Lipoxygenase
- lipoxygenase
- MCF-7 human breast adenocarcinoma cells
- calf thymus DNA
- breast adenocarcinoma
- apoptosis
- leukotrienes
- mitochondria
- cell cycle
- MRC-5 normal human fetal lung fibroblast cells
- glutathione
- Inhibitor
- inhibitor
- inhibit