VEGFR-2-IN-46
VEGFR-2-IN-46 (compound 4d) is a potent VEGFR-2 inhibitor with an EC50 value of 67.0 nM. VEGFR-2-IN-46 shows cytotoxicity and induces cell cycle arrest at the G2/M phase. VEGFR-2-IN-46 induces necrosis and apoptosis.
For research use only. We do not sell to patients.
- Formula: C23H18N2O4S
- Molecular Weight:418.47
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All VEGFR Isoforms
More
Biological Activity
VEGFR-2-IN-46 (compound 4d) shows cytotoxicity with IC50s of 501, 34.3, 25.0, 128.7 µM for HT-29, HeLa, HepG2, MCF10A cells, respectively[1].
VEGFR-2-IN-46 (25 µM; 72 h) induces cell cycle arrest at G2/M phase and necrosis, apoptosis in HepG2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HT-29, HeLa, HepG2, MCF10A cells
-
Concentration:
-
Incubation Time:
-
Result:Showed cytotoxicity with IC50s of 501, 34.3, 25.0, 128.7 µM for HT-29, HeLa, HepG2, MCF10A cells, respectively.
-
Cell Line:HepG2 cells
-
Concentration:25 µM
-
Incubation Time:72 h
-
Result:Induced cell cycle arrest at G2/M phase with the proportion of G2/M phase cell arrest at 79.7%.
-
Cell Line:HepG2 cells
-
Concentration:25 µM
-
Incubation Time:72 h
-
Result:Induced necrosis and apoptosis with the proportion of necrotic, and apoptotic cells of 46.6% and 32.6%, respectively.
Chemical Information
-
Molecular Weight 418.47
-
Formula C23H18N2O4S
-
SMILES
O=C(C1=CC=C(OC)C=C1)CSC2=NN=C(O2)C3=CC=CC(OC4=CC=CC=C4)=C3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)