EGFR/c-Met-IN-1
EGFR/c-Met-IN-1 (compound TS-41) is a dual-target inhibitor of EGFR/c-Met. The IC50 for inhibiting EGFRL858R and c-Met is 68.1 nM and 0.26 nM respectively. . EGFR/c-Met-IN-1 induces apoptosis and cell cycle arrest in A549-P cells, downregulating the phosphorylation of EGFR, c-Met, and downstream AKT. EGFR/c-Met-IN-1 inhibits tumor growth in vitro and in vivo.
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- CAS No.: 3020728-68-8
- 화학식: C30H25FN6O5
- 분자량:568.56
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
All EGFR Isoforms
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Biological Activity
IC50: 68.1 nM (EGFRL858R), 0.26 nM (c-Met)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
1.06 μM
Compound: 3
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Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 38733884] |
| PC-9 | IC50 |
1.05 μM
Compound: 3
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Antiproliferative activity against human PC-9 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human PC-9 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
|
[PMID: 38733884] |
Chemical Information
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CAS No. 3020728-68-8
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분자량 568.56
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화학식 C30H25FN6O5
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SMILES
O=C(C1=C(C)N(C)N(C2=CC=CC=C2)C1=O)NC3=CC=C(OC4=C5C=C(NC(C=C)=O)C(OC)=CC5=NC=N4)C(F)=C3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)