2. MAPK/ERK Pathway Apoptosis
  3. Raf Apoptosis
  4. B-Raf IN 9

B-Raf IN 9 (compound 8b) is a potent B-Raf inhibitor, with an IC50 of 24.79 nM. B-Raf IN 9 induces apoptosis and shows cell cycle arrest at G2/M phase. B-Raf IN 9 exhibits potent antitumor activity against human prostate cancer PC-3 cell line, with an IC50 of 7.83 µM.

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B-Raf IN 9 Chemical Structure

B-Raf IN 9 Chemical Structure

CAS No. : 2477725-18-9

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B-Raf IN 9 Related Antibodies

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Description

B-Raf IN 9 (compound 8b) is a potent B-Raf inhibitor, with an IC50 of 24.79 nM. B-Raf IN 9 induces apoptosis and shows cell cycle arrest at G2/M phase. B-Raf IN 9 exhibits potent antitumor activity against human prostate cancer PC-3 cell line, with an IC50 of 7.83 µM[1].

IC50 & Target

B-Raf

24.97 ± 0. nM (IC50)

Molecular Weight

400.50

Formula

C23H20N4OS
CAS No.
SMILES

S=C(NC1=CC=CC=C1)NC2=CC=C(C(CC3)=NN(C4=CC=CC=C4)C3=O)C=C2
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Purity & Documentation
References
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B-Raf IN 9 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

B-Raf IN 92477725-18-9RafApoptosisRaf kinasesPC-3 cellHEPG2MCF-7antitumorB-Rafcell cyclepyridazinoneprostate cancerInhibitorinhibitorinhibit

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