2477725-18-9
2477725-18-9
Chemical Structure
B-Raf IN 9
- CAS No.: 2477725-18-9
- Formula:C23H20N4OS
- Molecular Weight:400.50
IUPAC Name: 1-(4-(6-oxo-1-phenyl-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)-3-phenylthiourea
InChIKey: NNDKPTKCHFIEKG-UHFFFAOYSA-N
SMILES: S=C(NC1=CC=CC=C1)NC2=CC=C(C(CC3)=NN(C4=CC=CC=C4)C3=O)C=C2
Biological Activity: B-Raf IN 9 (compound 8b) is a potent B-Raf inhibitor, with an IC50 of 24.79 nM. B-Raf IN 9 induces apoptosis and shows cell cycle arrest at G2/M phase. B-Raf IN 9 exhibits potent antitumor activity against human prostate cancer PC-3 cell line, with an IC50 of 7.83 µM[1].
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B-Raf IN 9 | B-Raf IN 9 (compound 8b) is a potent B-Raf inhibitor, with an IC50 of 24.79 nM. B-Raf IN 9 induces apoptosis and shows cell cycle arrest at G2/M phase. B-Raf IN 9 exhibits potent antitumor activity against human prostate cancer PC-3 cell line, with an IC50 of 7.83 µM. | |||||||||||||||||||||
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References
Keywords
