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Cat. No.: HY-157814

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Menin-MLL inhibitor-25

Menin-MLL inhibitor-25 (compound A6) is a potent Menin-MLL interaction inhibitor with an IC₅₀ value of 0.38 µM. Menin-MLL inhibitor-25 shows anti-proliferative activity. Menin-MLL inhibitor-25 induces apoptosis and cell cycle arrest at G0/G1 phase. Menin-MLL inhibitor-25 reverses the differentiation arrest.

For research use only. We do not sell to patients.

Formula: C₂₈H₂₈FN₇
Molecular Weight:481.57

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

Menin-MLL inhibitor-25 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All Epigenetic Reader Domain Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	>10 μM Compound: A6	Antiproliferative activity against human HCT-116 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT-116 cells incubated for 72 hrs by MTT assay	[PMID: 38367493]
HL-60	IC₅₀	>10 μM Compound: A6	Antiproliferative activity against human HL-60 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HL-60 cells incubated for 72 hrs by MTT assay	[PMID: 38367493]
MCF7	IC₅₀	>10 μM Compound: A6	Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay	[PMID: 38367493]
MV4-11	IC₅₀	1.07 μM Compound: A6	Antiproliferative activity against human MV4-11 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MV4-11 cells incubated for 72 hrs by MTT assay	[PMID: 38367493]
NCM460	IC₅₀	>10 μM Compound: A6	Antiproliferative activity against human NCM460 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human NCM460 cells incubated for 72 hrs by MTT assay	[PMID: 38367493]
Pfeiffer	IC₅₀	>10 μM Compound: A6	Antiproliferative activity against human Pfeiffer cells incubated for 72 hrs by MTT assay Antiproliferative activity against human Pfeiffer cells incubated for 72 hrs by MTT assay	[PMID: 38367493]
Raji	IC₅₀	>10 μM Compound: A6	Antiproliferative activity against human Raji cells incubated for 72 hrs by MTT assay Antiproliferative activity against human Raji cells incubated for 72 hrs by MTT assay	[PMID: 38367493]
Ramos	IC₅₀	>10 μM Compound: A6	Antiproliferative activity against human Ramos cells incubated for 72 hrs by MTT assay Antiproliferative activity against human Ramos cells incubated for 72 hrs by MTT assay	[PMID: 38367493]
SU-DHL-6	IC₅₀	6.87 μM Compound: A6	Antiproliferative activity against human SU-DHL-6 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human SU-DHL-6 cells incubated for 72 hrs by MTT assay	[PMID: 38367493]

In Vitro

Menin-MLL inhibitor-25 (compound A6) (0-10 µM) shows anti-proliferation activity with IC₅₀s of 1.07, >10, 6.7 µM for MV4-11, HL-60, SU-DHL-6 cells, respectively. ^[1].
Menin-MLL inhibitor-25 (0.1, 1, 10 µM; 24 h) induces apoptosis and cell cycle arrest at G0/G1 phase in MV4-11 cells^[1].
Menin-MLL inhibitor-25 (0.1, 0.5 µM; 24, 48 h) decreases the HOXA9 and MEIS1 gene expression in a time and dose dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

MV4-11, HL-60, SU-DHL-6 cells
Concentration:

0-10 µM
Incubation Time:
Result:

Showed anti-proliferation activity with IC₅₀s of 1.07, >10, 6.7 µM for MV4-11, HL-60, SU-DHL-6 cells, respectively.

Apoptosis Analysis^[1]

Cell Line:

MV4-11 cells
Concentration:

0.1, 1, 10 µM
Incubation Time:

24 h
Result:

Induced apoptosis with the apoptosis rates of 6.09 %, 8.86 % and 43.08 % at 0.1, 1 and 10 μM.

Cell Cycle Analysis^[1]

Cell Line:

MV4-11 cells
Concentration:

0.01, 0.1, 1 µM
Incubation Time:

24 h
Result:

Induced cell cycle arrest at G0/G1 phase in a dose-dependent manner.

RT-PCR^[1]

Cell Line:

MV4-11 cells
Concentration:

0.1, 0.5 µM
Incubation Time:

24, 48 h
Result:

Decreasesd the gene expression of HOXA9 and MEIS1 in a time and dose dependent manner.

Chemical Information

Molecular Weight 481.57
Formula C₂₈H₂₈FN₇
SMILES

N#CC1=CC=C(N2CC(CN3CCC(N4C=C(C5=CC=C(F)C=C5)C6=C(N)N=CN=C64)CC3)C2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bai H, et al. Discovery of novel pyrrolo[2,3-d]pyrimidines as potent menin-mixed lineage leukemia interaction inhibitors. Eur J Med Chem. 2024 Feb 8;268:116226. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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Menin-MLL inhibitor-25

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