MR24
MR24, a G-5555 (HY-19635) derivative, is a mammalian STE20-like (MST) kinase inhibitor. MR24 shows selectively to MST3/4 over MST1/2, with EC50 values of 57 and 583 nM, respectively. MR24 induces G1 phase cell cycle arrest. MR24 can be used for cancer research, such as breast, liver and lung cancers.
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- CAS No.: 3056814-89-9
- 화학식: C26H29ClN6O3
- 분자량:509.00
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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MST3 57 nM (EC50) |
MST4 583 nM (EC50) |
MR24 (compound 24) (1-10 μM, 6-72 h) shows no significant effect on cell healthy nuclei in HCT116 cells, and only results in a slight reduction in cell viability by about 30% at a concentration of 10 μM[1].
MR24 (1-10 μM, 24-72 h) induces G1 phase cell cycle arrest in HCT116 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT116 cells
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Concentration:1, 5, and 10 μM
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Incubation Time:24, 48 and 72 h
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Result:Increased the fraction of cells in the G1 phase at 10 μM.
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Cell Line:HCT116 cells
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Concentration:1 and 10 μM
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Incubation Time:6, 12, 24, 48 and 72 h
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Result:Showed no significant effect on the normalized cell count at a concentration of 1 μM.
Resulted in a slight reduction in cell viability by about 30% at a concentration of 10 μM.
Resulted in over 90% healthy nuclei after 24 h at both concentrations used (1 and 10 μM).
Chemical Information
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CAS No. 3056814-89-9
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분자량 509.00
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화학식 C26H29ClN6O3
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SMILES
CC1=CC=CC(C2=CC(Cl)=C(C=C2)C3=CC4=C(N(C3=O)CCCCN)N=C(N=C4)NC(CO)CO)=N1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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