MR24 TFA
Based on 1 Customer Validation
MR24 TFA, a G-5555 (HY-19635) derivative, is a mammalian STE20-like (MST) kinase inhibitor. MR24 TFA shows selectively to MST3/4 over MST1/2, with EC50 values of 57 and 583 nM, respectively. MR24 TFA induces G1 phase cell cycle arrest. MR24 TFA can be used for cancer research, such as breast, liver and lung cancers.
For research use only. We do not sell to patients.
- Purity: 99.13%
- Formula: C28H30ClF3N6O5
- Molecular Weight:623.02
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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MST3 57 nM (EC50) |
MST4 583 nM (EC50) |
MR24 (compound 24) (1-10 μM, 6-72 h) TFA shows no significant effect on cell healthy nuclei in HCT116 cells, and only results in a slight reduction in cell viability by about 30% at a concentration of 10 μM[1].
MR24 (1-10 μM, 24-72 h) TFA induces G1 phase cell cycle arrest in HCT116 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT116 cells
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Concentration:1, 5, and 10 μM
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Incubation Time:24, 48 and 72 h
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Result:Increased the fraction of cells in the G1 phase at 10 μM.
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Cell Line:HCT116 cells
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Concentration:1 and 10 μM
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Incubation Time:6, 12, 24, 48 and 72 h
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Result:Showed no significant effect on the normalized cell count at a concentration of 1 μM.
Resulted in a slight reduction in cell viability by about 30% at a concentration of 10 μM.
Resulted in over 90% healthy nuclei after 24 h at both concentrations used (1 and 10 μM).
Chemical Information
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Appearance Solid
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Molecular Weight 623.02
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Formula C28H30ClF3N6O5
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Color Light yellow to yellow
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SMILES
CC1=CC=CC(C2=CC(Cl)=C(C=C2)C3=CC4=C(N(C3=O)CCCCN)N=C(N=C4)NC(CO)CO)=N1.OC(C(F)(F)F)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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