1. Apoptosis
  2. Apoptosis
  3. MBM-17

MBM-17 

Cat. No.: HY-101030
Handling Instructions

MBM-17 (compound 42c) is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 3 nM. It effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. MBM-55 shows antitumor activities, and no obvious toxicity to mice.

For research use only. We do not sell to patients.

MBM-17 Chemical Structure

MBM-17 Chemical Structure

CAS No. : 2083621-90-1

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Description

MBM-17 (compound 42c) is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 3 nM. It effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. MBM-55 shows antitumor activities, and no obvious toxicity to mice[1].

IC50 & Target

IC50: 3 nM (Nek2), 5800 nM (Aurora A)[1]

In Vitro

MBM-17 inhibits MGC-803, HCT-116, Bel-7402 cells proliferation with IC50s of 0.48, 1.06, 4.53 μM, respectively[1].

Molecular Weight

480.56

Formula

C₂₈H₂₈N₆O₂

CAS No.

2083621-90-1

SMILES

NC(C(C=C1)=C(OCC2=CC=CC=C2)C=C1C3=CN=C4N3C=CC(C5=CN(CCN(C)C)N=C5)=C4)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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