Sodium citrate monobasic
Based on 1 Customer Validation
Sodium citrate monobasic (Citric acid monosodium salt) is a natural preservative and food tartness enhancer. Sodium citrate monobasic induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Sodium citrate monobasic cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Sodium citrate monobasic is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 18996-35-5
- Formula: C6H7NaO7
- Molecular Weight:214.11
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Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Sodium citrate monobasic (0-12.5 mM; 24 h) shows antiproliferative activity in a dose dependent manner[3].
Sodium citrate monobasic (12.5 mM; 72 h) induces apoptosis and cell cycle arrest at G2/M phase and S phase in a dosedependent manner[3].
Sodium citrate monobasic (12.5 mM; 48 h) increases the expression of FAS, BAX, BID, AIF, EndoG, cytochrome c, PARP, GADD153, GRP78 and caspase-3, -8, -9, and decreases of BCL-2 and BCL-Xl[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HaCaT cells
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Concentration:0, 2.5, 5, 7.5, 10, 12.5 mM
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Incubation Time:24 h
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Result:Inhibited the cell viability in a dose dependent manner.
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Cell Line:HaCaT cells
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Concentration:12.5 mM
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Incubation Time:0, 12, 24, 48, 72 h
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Result:Induced apoptosis and cell cycle arrest at G2/M phase and S phase in a dose-dependent manner.
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Cell Line:HaCaT cells
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Concentration:12.5 mM
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Incubation Time:12, 24, 48, 72 h
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Result:Increased the expression of FAS, BAX, BID, AIF, EndoG, cytochrome c, PARP, GADD153, GRP78 and caspase-3, -8, -9, and decreased of BCL-2 and BCL-Xl.
Sodium citrate monobasic (120, 240, and 480 mg/kg; i.p.) induces apoptosis by increases caspase-3 activity in a dose-dependent manner in mouse hepatocytes[1].
Sodium citrate monobasic (120, 240, and 480 mg/kg; i.p.; weekly for 3 weeks) causes renal toxicity in mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:20 g male Kunming mice[2]
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Dosage:120, 240, 480 mg/kg
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Administration:i.p.; weekly for 3 weeks
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Result:T-SOD and GSH-Px activities in the treated groups decreased with increasing doses of citric acid, NOS activity tended to increase, and H2O2 and MDA contents gradually decreased.
Chemical Information
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CAS No. 18996-35-5
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Appearance Solid
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Molecular Weight 214.11
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Formula C6H7NaO7
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Color White to off-white
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SMILES
O=C(O[Na])CC(C(O)=O)(O)CC(O)=O
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Synonyms
Citric acid monosodium salt
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Solvent & Solubility
H2O : 50 mg/mL (233.52 mM; ultrasonic and warming and heat to 60°C)
DMSO : 2 mg/mL (9.34 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Chen X, et al. Study on injury effect of food additive citric acid on liver tissue in mice. Cytotechnology. 2014 Mar;66(2):275-82. [Content Brief]
[2]. Chen X, Lv Q, Liu Y, Deng W. Effects of the food additive, citric acid, on kidney cells of mice. Biotech Histochem. 2015 Jan;90(1):38-44. [Content Brief]
[3]. Ying TH, et al. Citric acid induces cell-cycle arrest and apoptosis of human immortalized keratinocyte cell line (HaCaT) via caspase- and mitochondrial-dependent signaling pathways. Anticancer Res. 2013 Oct;33(10):4411-20. [Content Brief]
[4]. Ciriminna R, et al. Citric acid: emerging applications of key biotechnology industrial product. Chem Cent J. 2017 Mar 8;11:22. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 4.6705 mL | 23.3525 mL | 46.7050 mL | 116.7624 mL |
| 5 mM | 0.9341 mL | 4.6705 mL | 9.3410 mL | 23.3525 mL | |
| H2O | 10 mM | 0.4670 mL | 2.3352 mL | 4.6705 mL | 11.6762 mL |
| 15 mM | 0.3114 mL | 1.5568 mL | 3.1137 mL | 7.7842 mL | |
| 20 mM | 0.2335 mL | 1.1676 mL | 2.3352 mL | 5.8381 mL | |
| 25 mM | 0.1868 mL | 0.9341 mL | 1.8682 mL | 4.6705 mL | |
| 30 mM | 0.1557 mL | 0.7784 mL | 1.5568 mL | 3.8921 mL | |
| 40 mM | 0.1168 mL | 0.5838 mL | 1.1676 mL | 2.9191 mL | |
| 50 mM | 0.0934 mL | 0.4670 mL | 0.9341 mL | 2.3352 mL | |
| 60 mM | 0.0778 mL | 0.3892 mL | 0.7784 mL | 1.9460 mL | |
| 80 mM | 0.0584 mL | 0.2919 mL | 0.5838 mL | 1.4595 mL | |
| 100 mM | 0.0467 mL | 0.2335 mL | 0.4670 mL | 1.1676 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Sodium citrate monobasic Related Classifications
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