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Anticancer agent 53 

Cat. No.: HY-146407
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Anticancer agent 53 is a potent anticancer agent. Anticancer agent 53 shows in vitro cytotoxicity. Anticancer agent 53 induces apoptosis and cell cycle arrest in S/G2/M phases. Anticancer agent 53 shows antitumor activity with no apparent toxicity.

For research use only. We do not sell to patients.

Anticancer agent 53 Chemical Structure

Anticancer agent 53 Chemical Structure

CAS No. : 1926985-18-3

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Description

Anticancer agent 53 is a potent anticancer agent. Anticancer agent 53 shows in vitro cytotoxicity. Anticancer agent 53 induces apoptosis and cell cycle arrest in S/G2/M phases. Anticancer agent 53 shows antitumor activity with no apparent toxicity[1].

In Vitro

Anticancer agent 53 (compound c20) (0-1000 nM; 72 h) shows cytotoxicity with IC50s of 2.3, 42.0, 4.3, 96.3, 24.0, 47.4 nM for Hep3B, MCF7, A549, MDA-MB-231, KB, KB-vin cells, respectively[1].
Anticancer agent 53 (0.025, 0.05, 0.1 µM; 48 h) induces apoptosis and cell cycle arrest in S/G2/M phases[1].
Anticancer agent 53 (0.1. 0.2 µM; 6 h) inhibits topoisomerase I activity in A549 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis[1]

Cell Line: A549 cells
Concentration: 0.025, 0.05, 0.1 µM
Incubation Time: 0-48 h
Result: Induced cell cycle arrest in S/G2/M phases.

Apoptosis Analysis[1]

Cell Line: A549 cells
Concentration: 0.025, 0.05, 0.1 µM
Incubation Time: 0-48 h
Result: Induced apoptosis with the proapoptotic protein Caspase-3 and Bax were up-regulated and anti-apoptotic Bcl-2 was down-regulated.
In Vivo

Anticancer agent 53 (5, 25 and 50 mg/kg; IP) shows no apparent toxicity to mouse liver, kidney and hemopoietic system[1].
Anticancer agent 53 (2 mg/kg; i.v; every other day for two weeks) shows antitumor effect in HCC mouse model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/C mice[1]
Dosage: 5, 25 and 50 mg/kg (saline with 5% DMSO and 5% Cremophor EL)
Administration: I.p.
Result: Showed no body weight loss, no significant liver damage, no significant damage occurred in spleens and livers.
Animal Model: 6-8 weeks Female BALB/c nude mice (Hep3B cells)[1]
Dosage: 1, 2 mg/kg
Administration: I.v., every other day for total 7 doses
Result: Significantly inhibited tumor growth with an average body weight of 24 g and an average tumor volume of 3800 mm[3] at 1 mg/kg and an average body weight of 22 g and average tumor volume 2380 mm[3] at 2 mg/kg.
Animal Model: 6-8 weeks FVB/N mice (HCC mouse model)[1]
Dosage: 2 mg/kg
Administration: I.v.; every other day for two weeks
Result: Inhibited the tumor growth and reduced the liver weights, and t inhibited proliferation of HCC tissues.
Molecular Weight

600.62

Formula

C31H25FN4O6S

CAS No.
SMILES

CC[[email protected]]1(C(OCC2=C1C=C3C4=NC5=CC=CC=C5C=C4CN3C2=O)=O)OC([[email protected]@H](NC(NC(C6=CC=C(C=C6)F)=O)=S)C)=O

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Anticancer agent 53
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