1. Cell Cycle/DNA Damage
    Cytoskeleton
    Apoptosis
  2. Microtubule/Tubulin
    Apoptosis
  3. Tubulysin G

Tubulysin G 

Cat. No.: HY-N7050
Handling Instructions

Tubulysin G is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range. Tubulysin G is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis.

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Tubulysin G Chemical Structure

Tubulysin G Chemical Structure

CAS No. : 799822-08-5

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Description

Tubulysin G is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range[1]. Tubulysin G is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis[2].

Molecular Weight

842.05

Formula

C₄₃H₆₃N₅O₁₀S

CAS No.

799822-08-5

SMILES

O=C(N[[email protected]@H]([[email protected]@H](C)CC)C(N(COC(/C=C(C)/C)=O)[[email protected]@H](C(C)C)C[[email protected]@H](OC(C)=O)C1=NC(C(N[[email protected]@H](CC2=CC=C(O)C=C2)C[[email protected]](C)C(O)=O)=O)=CS1)=O)[[email protected]@H]3N(C)CCCC3

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Keywords:

Tubulysin GMicrotubule/TubulinApoptosisInhibitorinhibitorinhibit

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