1. Cell Cycle/DNA Damage
    Epigenetics
    Apoptosis
  2. HDAC
    Apoptosis
  3. HDAC1/6-IN-1

HDAC1/6-IN-1 

Cat. No.: HY-144725
Handling Instructions

HDAC1/6-IN-1 (compound D7) is a potent multitarget inhibitor of GLP, HDAC6 and HDAC1, with IC50 values of 1.3, 13, and 89 nM, respectively. HDAC1/6-IN-1 can inhibit the methylation and deacetylation of H3K9 on protein level. HDAC1/6-IN-1 induces cancer cell apoptosis, G0/G1 cell cycle arrest, and blocks migration and invasion.

For research use only. We do not sell to patients.

HDAC1/6-IN-1 Chemical Structure

HDAC1/6-IN-1 Chemical Structure

CAS No. : 2630989-02-3

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Description

HDAC1/6-IN-1 (compound D7) is a potent multitarget inhibitor of GLP, HDAC6 and HDAC1, with IC50 values of 1.3, 13, and 89 nM, respectively. HDAC1/6-IN-1 can inhibit the methylation and deacetylation of H3K9 on protein level. HDAC1/6-IN-1 induces cancer cell apoptosis, G0/G1 cell cycle arrest, and blocks migration and invasion[1].

IC50 & Target

HDAC6

13 nM (IC50)

HDAC1

89 nM (IC50)

Molecular Weight

591.74

Formula

C32H45N7O4

CAS No.
SMILES

COC1=C(C=C2C(N=C(N=C2NC3CCN(CC3)CC4=CC=CC=C4)N5CCN(CC5)CCCCCC(NO)=O)=C1)OC

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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HDAC1/6-IN-1
Cat. No.:
HY-144725
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