HDAC1/6-IN-1
HDAC1/6-IN-1 (compound D7) is a potent multitarget inhibitor of GLP, HDAC6 and HDAC1, with IC50 values of 1.3, 13, and 89 nM, respectively. HDAC1/6-IN-1 can inhibit the methylation and deacetylation of H3K9 on protein level. HDAC1/6-IN-1 induces cancer cell apoptosis, G0/G1 cell cycle arrest, and blocks migration and invasion.
For research use only. We do not sell to patients.
- CAS No.: 2630989-02-3
- Formula: C32H45N7O4
- Molecular Weight:591.74
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
HDAC6 13 nM (IC50) |
HDAC1 89 nM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | IC50 |
2.38 μM
Compound: D7
|
Antiproliferative activity against human A-431 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human A-431 cells measured after 72 hrs by MTT assay
|
[PMID: 34847495] |
| HCT-116 | IC50 |
11.05 μM
Compound: D7
|
Antiproliferative activity against human HCT-116 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells measured after 72 hrs by MTT assay
|
[PMID: 34847495] |
| HeLa | IC50 |
3.34 μM
Compound: D7
|
Antiproliferative activity against human HeLa cells measured after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells measured after 72 hrs by MTT assay
|
[PMID: 34847495] |
| HepG2 | IC50 |
2.74 μM
Compound: D7
|
Antiproliferative activity against human HepG2 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells measured after 72 hrs by MTT assay
|
[PMID: 34847495] |
| HT-29 | IC50 |
6.99 μM
Compound: D7
|
Antiproliferative activity against human HT-29 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human HT-29 cells measured after 72 hrs by MTT assay
|
[PMID: 34847495] |
| K562 | IC50 |
2.6 μM
Compound: D7
|
Antiproliferative activity against human K562 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human K562 cells measured after 72 hrs by MTT assay
|
[PMID: 34847495] |
| L02 | IC50 |
39.81 μM
Compound: D7
|
Cytotoxicity against human HL7702 cells measured after 72 hrs by MTT assay
Cytotoxicity against human HL7702 cells measured after 72 hrs by MTT assay
|
[PMID: 34847495] |
| MDA-MB-231 | IC50 |
9.3 μM
Compound: D7
|
Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by MTT assay
|
[PMID: 34847495] |
Chemical Information
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CAS No. 2630989-02-3
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Molecular Weight 591.74
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Formula C32H45N7O4
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SMILES
COC1=C(C=C2C(N=C(N=C2NC3CCN(CC3)CC4=CC=CC=C4)N5CCN(CC5)CCCCCC(NO)=O)=C1)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)