2. Cell Cycle/DNA Damage Apoptosis
  3. DNA/RNA Synthesis Apoptosis
  4. BLM-IN-2

BLM-IN-2 is a Bloom's Syndrome Protein (BLM) inhibitor with an IC50 value of 0.8 μM. BLM-IN-2 effectively suppresses the proliferation, invasion, cell cycle arrest and apoptosis of CRC cells. BLM-IN-2 can be used for the reserarch of colorectal cancer (CRC).

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BLM-IN-2 Chemical Structure

BLM-IN-2 Chemical Structure

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BLM-IN-2 Related Antibodies

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Description

BLM-IN-2 is a Bloom's Syndrome Protein (BLM) inhibitor with an IC50 value of 0.8 μM. BLM-IN-2 effectively suppresses the proliferation, invasion, cell cycle arrest and apoptosis of CRC cells. BLM-IN-2 can be used for the reserarch of colorectal cancer (CRC)[1].

IC50 & Target

IC50: 0.8 μM (BLM)[1]
In Vitro

BLM-IN-2 (0-20 μM) has good inhibitory effect on BLM unwinding and binding DNA with IC50 values of 0.8 μM and 2.3 μM, respectively[1].
BLM-IN-2 exhibits the potent BLM-dependent cytotoxicity against the CRC cells but weak against normal cells[1].
BLM-IN-2 (3 μM; 48 h) disrupts the HRR level while inhibiting BLM located on the DSB site and trigger DNA damage in the CRC cells[1].
BLM-IN-2 (0-5 μM; 48 h) effectively suppresses the proliferation and invasion of CRC cells, along with cell cycle arrest and apoptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BLM-IN-2 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HCT116 cells; HCT116, SW480 and RKO cells
Concentration: 0-5 μM; 0.5, 1, 2 μM
Incubation Time: 48 h; 10 days
Result: Induced proliferation arrest.
Completely inhibited the growth of cancer cells at the concentration around 2 μM, had a good anti-CRC activity.

Apoptosis Analysis[1]

Cell Line: HCT116, SW480 and RKO cells
Concentration: 1 μM
Incubation Time: 48 h
Result: Induced apoptosis and necrosis in HCT116, SW480 and RKO.

Cell Cycle Analysis[1]

Cell Line: HCT116, SW480 and RKO cells
Concentration: 4 μM
Incubation Time: 48 h
Result: Changed the cell proportion of the S or G2/M phase in CRC cells, arrested the cell cycle at the S phase in HCT116 and SW480 and arrested the cell cycle of HCT116, SW480 and RKO at the G2/M phase.

Cell Invasion Assay[1]

Cell Line: HCT116 cells
Concentration: 0.25, 0.5, 1, 2, 4 μM
Incubation Time: 48 h
Result: Obviously decreased the invasion in HCT116 cells with an IC50 value of 1.0 μM and had inhibitory on CRC invasion.
Molecular Weight

605.58

Formula

C33H38BrFN4O
SMILES

CCN(CCCNC1=C(C=C2C(N(C(/C=C/C3=CC=C(C=C3)C(C)C)=NC2=C1)CC4=CC=C(C=C4)Br)=O)F)CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BLM-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BLM-IN-2DNA/RNA SynthesisApoptosishomologous recombination repair (HRR)double-strand breaks (DSB)Bloom's Syndrome Protein (BLM)colorectal cancer (CRC)Inhibitorinhibitorinhibit

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