EGFR-IN-131
EGFR-IN-131 (compound 3a) is a potent and cross the blood-brain barrier EGFR inhibitor with an IC50 value of 272.9 nM. EGFR-IN-131 shows antiproliferative activity. EGFR-IN-131 induces apoptosis and cell cycle arrest at G0/G1 phase. EGFR-IN-131 decreases the protein expression of p-EGFR.
For research use only. We do not sell to patients.
- Formula: C26H23FN4O2S
- Molecular Weight:474.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All EGFR Isoforms
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Biological Activity
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EGFR 272.9 nM (IC50) |
Chemical Information
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Molecular Weight 474.55
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Formula C26H23FN4O2S
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SMILES
CC(C1=CC(NC2=CC3=CC=N2)=CC=C1)OCCCC(NC4=NC(C5=CC=C(C=C5)F)=C3S4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)