SLC7A11-IN-1
Based on 1 Customer Validation
SLC7A11-IN-1 is a potent solute carrier family 7 member 11 (SLC7A11, xCT) inhibitor. SLC7A11-IN-1 shows antiproliferative activity. SLC7A11-IN-1 inhibits cell invasion and metastasis. SLC7A11-IN-1 induces Apoptosis and cell cycle arrest at S-phase. SLC7A11-IN-1 shows anti-tumor activity.
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- Reinheit : 97.06%
- CAS. Nr.: 3049302-90-8
- Formel: C13H17Cl2F3N4O5PtS
- Molecular Weight:664.35
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
SLC7A11[1]
In Vitro
SLC7A11-IN-1 (compound 2; 0-100 µM; 72 h) shows antiproliferative activity with IC50s of 0.03, 0.11, 0.18, 0.17, 0.27 µM for HCT-116, MDA-MB-231, MCF-7, HepG2, LO2 cells, respectively[1].
SLC7A11-IN-1 (0.5 µM; 24 h) inhibits invasion and metastasis of HCT-116 cells[1].
SLC7A11-IN-1 (0.5 µM; 24 h) induces cell apoptosis and cell cycle arrest at S-phase[1].
SLC7A11-IN-1 obviously reduces the intracellular GSH content and significantly enhances reactive oxygen species (ROS) expression[1].
SLC7A11-IN-1 (1 µM; 15 h) significantly induced DNA damage and related proteins expression in HCT-116 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT-116 cells
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Concentration:0.5 µM
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Incubation Time:24 h
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Result:Induced cell apoptosis and cell cycle arrest at S-phase with the S-phase proportion of 55.79%.
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Cell Line:HCT-116 cells
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Concentration:1 µM
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Incubation Time:15 h
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Result:Increased the expression of p53, Bax, p-Akt, VEGFA and HIF1-α proteins, decreased the expression of Bcl-2, xCT protein level.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:male BALB/c mice (CT26 tumor models)[1]
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Dosage:2 mg/kg
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Administration:I.v.; once every three days, for consecutive 3 times
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Result:Suppressed the growth of tumor by 60.7%.
- Spheroid/Tumor Organoid Invasion Assay
- Ex Vivo Tissue Slice/Explant Invasion Assay
- Patient-Derived Organoid Invasion Assay
- Annexin V plus membrane-impermeant dye apoptosis staining
- BrdU Incorporation Assay
- Protocol for Cell Cycle
- 3D Tumor Spheroid Invasion Assay
- Cell Viability Determination by MTT Colorimetric Assay
- Matrigel Transwell/Boyden Chamber Invasion Assay
- Invadopodia/Fluorescent Gelatin Degradation Assay
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- Flow cytometric DNA-content cell-cycle staining
- Organotypic 3D Invasion Assay
- Apoptosis Solutions
- Cell invasion
- Matrigel/ECM Transwell Invasion Assay
- Ferroptosis Solutions
- Orthotopic Cell-Line Xenograft
- 3D Collagen/Hydrogel Matrix Invasion Assay
Chemical Information
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CAS. Nr. 3049302-90-8
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Appearance Solid
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Molecular Weight 664.35
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Formel C13H17Cl2F3N4O5PtS
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Color White to off-white
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SMILES
[NH3][Pt+4]([OH-])([Cl-])([Cl-])([O-]C(CCCC(NC1=NC2=CC=C(C=C2S1)OC(F)(F)F)=O)=O)[NH3]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
SLC7A11-IN-1 Related Classifications
HY-149979 Related Classifications
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