2. Apoptosis
  3. Apoptosis
  4. SLC7A11-IN-1

SLC7A11-IN-1 is a potent solute carrier family 7 member 11 (SLC7A11, xCT) inhibitor. SLC7A11-IN-1 shows antiproliferative activity. SLC7A11-IN-1 inhibits cell invasion and metastasis. SLC7A11-IN-1 induces Apoptosis and cell cycle arrest at S-phase. SLC7A11-IN-1 shows anti-tumor activity.

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SLC7A11-IN-1

SLC7A11-IN-1 Chemical Structure

CAS No. : 3049302-90-8

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Based on 1 publication(s) in Google Scholar

SLC7A11-IN-1 Related Antibodies

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Description

SLC7A11-IN-1 is a potent solute carrier family 7 member 11 (SLC7A11, xCT) inhibitor. SLC7A11-IN-1 shows antiproliferative activity. SLC7A11-IN-1 inhibits cell invasion and metastasis. SLC7A11-IN-1 induces Apoptosis and cell cycle arrest at S-phase. SLC7A11-IN-1 shows anti-tumor activity[1].

IC50 & Target

SLC7A11[1]
In Vitro

SLC7A11-IN-1 (compound 2; 0-100 µM; 72 h) shows antiproliferative activity with IC50s of 0.03, 0.11, 0.18, 0.17, 0.27 µM for HCT-116, MDA-MB-231, MCF-7, HepG2, LO2 cells, respectively[1].
SLC7A11-IN-1 (0.5 µM; 24 h) inhibits invasion and metastasis of HCT-116 cells[1].
SLC7A11-IN-1 (0.5 µM; 24 h) induces cell apoptosis and cell cycle arrest at S-phase[1].
SLC7A11-IN-1 obviously reduces the intracellular GSH content and significantly enhances reactive oxygen species (ROS) expression[1].
SLC7A11-IN-1 (1 µM; 15 h) significantly induced DNA damage and related proteins expression in HCT-116 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SLC7A11-IN-1 Related Antibodies

Cell Cycle Analysis[1]

Cell Line: HCT-116 cells
Concentration: 0.5 µM
Incubation Time: 24 h
Result: Induced cell apoptosis and cell cycle arrest at S-phase with the S-phase proportion of 55.79%.

Western Blot Analysis[1]

Cell Line: HCT-116 cells
Concentration: 1 µM
Incubation Time: 15 h
Result: Increased the expression of p53, Bax, p-Akt, VEGFA and HIF1-α proteins, decreased the expression of Bcl-2, xCT protein level.
In Vivo

SLC7A11-IN-1 (2 mg/kg; i.v.; every three days for consecutive 3 times) inhibits the growth of tumors in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: male BALB/c mice (CT26 tumor models)[1]
Dosage: 2 mg/kg
Administration: I.v.; once every three days, for consecutive 3 times
Result: Suppressed the growth of tumor by 60.7%.
Molecular Weight

664.35

Formula

C13H17Cl2F3N4O5PtS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[NH3][Pt+4]([OH-])([Cl-])([Cl-])([O-]C(CCCC(NC1=NC2=CC=C(C=C2S1)OC(F)(F)F)=O)=O)[NH3]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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SLC7A11-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SLC7A11-IN-13049302-90-8ApoptosisHCT-116 cellsantiproliferativeinvasionmetastasiGSHROSapoptosisanti-tumorInhibitorinhibitorinhibit

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