1. Membrane Transporter/Ion Channel
    Apoptosis
  2. Na+/K+ ATPase
    Apoptosis
  3. Neriifolin

Neriifolin (Synonyms: 17β-Neriifolin)

Cat. No.: HY-N8441 Purity: ≥96.0%
Handling Instructions

Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na+, K+-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells[2.

For research use only. We do not sell to patients.

Neriifolin Chemical Structure

Neriifolin Chemical Structure

CAS No. : 466-07-9

Size Price Stock Quantity
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na+, K+-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells[1][2.

In Vitro

Neriifolin (0.1μg/mL; 48 hours) induces apoptosis in HepG2 cells. Neriifolin (0-8 μg/mL; 72 hours) reduces viability of HepG2 cells. Neriifolin also induces S and G2/M phase arrests of the cell cycle and stimulates apoptosis of HepG2 cells. Stimulation of HepG2 cells with Neriifolin induced activation of caspase-3, -8, and -9, and up-regulated expression of Fas and FasL proteins[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

534.68

Formula

C₃₀H₄₆O₈

CAS No.
SMILES

O[[email protected]@]12[[email protected]@]3([H])[[email protected]@](CC[[email protected]@]1([[email protected]](C4=CC(OC4)=O)([H])CC2)C)([H])[[email protected]@]5([[email protected]](C[[email protected]](CC5)O[[email protected]]6[[email protected]]([[email protected]@H]([[email protected]]([[email protected]@H](O6)C)O)OC)O)([H])CC3)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
References

Purity: ≥96.0%

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Neriifolin17β-NeriifolinNa+/K+ ATPaseApoptosisSodium potassium pumpexperimentalautoimmuneencephalomyelitisphagosomesHepG2cellsCNSinflammationInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Neriifolin
Cat. No.:
HY-N8441
Quantity:
MCE Japan Authorized Agent: