466-07-9
Chemical Structure
Neriifolin
Synonym(s): 17β-Neriifolin
- CAS No.: 466-07-9
- Formula:C30H46O8
- Molecular Weight:534.68
IUPAC Name: 4-((3S,5R,8R,9S,10S,13R,14S,17R)-3-(((2R,3S,4R,5S,6S)-3,5-dihydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)furan-2(5H)-one
InChIKey: VPUNMTHWNSJUOG-BAOINKAISA-N
SMILES: O[C@@]12[C@@]3([H])[C@@](CC[C@@]1([C@](C4=CC(OC4)=O)([H])CC2)C)([H])[C@@]5([C@](C[C@H](CC5)O[C@H]6[C@H]([C@@H]([C@H]([C@@H](O6)C)O)OC)O)([H])CC3)C
Biological Activity: Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na+, K+-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells[1][2.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Neriifolin | 99.70% | Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na+, K+-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells[2. | ||||||||||||||||||||
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Peruvoside | 99.32% | Peruvoside is a potent inhibitor of Src, PI3K, JNK, STAT, and EGFR. Peruvoside induces apoptosis and autophagy and possesses a broad spectrum of anticancer activity in breast, lung, liver cancers and leukemia. Peruvoside is a broad-spectrum and potent antiviral activity against positive-sense RNA viruses. Peruvoside sensitizes Gefitinib (HY-50895)-resistant tumour cells (A549, PC9/gef and H1975) to Gefitinib. | ||||||||||||||||||||
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Odoroside H | 98% | Odoroside H is a natural cardenolide with anticancer activities. | ||||||||||||||||||||
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Uzarigenin digitaloside | Uzarigenin digitaloside is a Steroids product that can be isolated from the herbs of Nerium oleander. | |||||||||||||||||||||
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Strospeside | Strospeside (Gitoxigenin 3-O-monodigitaloside) is a cardenolide and can be isolated from Cuscuta shoot. Strospeside has potent cytotoxicity against renal and prostate cancer cell lines. | |||||||||||||||||||||
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Digitoxigenin-3-O-β-D-quinovoside | Digitoxigenin-3-O-β-D-quinovoside is an interleukin-2 (IL-2)/luciferase inhibitor with an IC50 value of 52 nM. Digitoxigenin-3-O-β-D-quinovoside is a cardiac lactone isolated from Elaeodendron australe var. integrifolium. | |||||||||||||||||||||
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17α-Neriifolin | 17α-Neriifolin is a compound isolated from a methylene chloride extract of the seeds of Cerbera odollam. | |||||||||||||||||||||
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Odoroside | Odoroside (Solanoside) is a cardiac glycoside present in oleander (Nerium oleander L). | |||||||||||||||||||||
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Odoroside A | 99.73% | Odoroside A is an active ingredient extracted from the leaves of Nerium oleander Linn. Odoroside A has anti-cancer activity. Odoroside A could induce apoptosis and cell cycle arrest through ROS/p53 signaling pathway, leading to the tumor cell death. | ||||||||||||||||||||
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Evomonoside | Evomonoside is a type of cardiac glycoside compound. Evomonoside exhibits significant in vitro anticancer activity, especially having nanomolar inhibitory concentrations against gastric cancer cell lines. Evomonoside has typical cardiac toxicity risks, including arrhythmias and conduction abnormalities. Evomonoside can be used for research on gastric cancer. | |||||||||||||||||||||
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Cerberin | Cerberin is a cardiac glycoside that has been found in C. odollam and has cytotoxic and cardiac modulatory activities. It is cytotoxic to KB and NCI H187 cancer cells (IC50s=1.92 and 1.24 μg/mL).1 Cerberin inhibits Na+/K+-ATPase, increasing intracellular sodium levels and action potential duration in cardiac cells. | |||||||||||||||||||||
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