Neriifolin from seeds of Cerbera manghas L. induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells

  • Fitoterapia. 2011 Jul;82(5):735-41. doi: 10.1016/j.fitote.2011.03.004.
Qian Zhao  1 ,  Yuewei Guo ,  Bo Feng ,  Liang Li ,  Caiguo Huang ,  Binghua Jiao
Affiliations
  • 1. Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, People's Republic of China.
PMID: 21459134 DOI: 10.1016/j.fitote.2011.03.004
Abstract

The effects of neriifolin, a cardiac glycoside from Cerbera manghas L. on various end-points of oncologic relevance (cell growth, cell cycle regulation, and Apoptosis in HepG2 cells) were investigated. Neriifolin reduced viability of HepG2 cells, induced S and G2/M phase arrests of the cell cycle, and stimulated Apoptosis of HepG2 cells. Stimulation of HepG2 cells with neriifolin induced activation of Caspase-3, -8, and -9, and up-regulated expression of Fas and FasL proteins. Based on these results, neriifolin could be considered a candidate for the treatment of hepatocellular carcinoma.

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