12-Deoxyphorbol 13-palmitate

Cat. No.: HY-N13201: Data Sheet Handling Instructions
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12-Deoxyphorbol 13-palmitate is a traditional Chinese medicine monomer with antitumor activity that can be isolated from the root of Euphorbia fischeriana. 12-Deoxyphorbol 13-palmitate induces gastric cancer cell cycle arrest and apoptosis by regulating key cell cycle regulators such as cyclin B、cyclin A and CDC2. In addition, 12-Deoxyphorbol 13-palmitate can significantly weaken APOL2–SERCA2–PERK–HES1 signaling and slow liver fibrosis by targeting APOL2.

For research use only. We do not sell to patients.

12-Deoxyphorbol 13-palmitate Chemical Structure

CAS No. : 66583-59-3

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

586.84

Formula

C₃₆H₅₈O₆

CAS No.

66583-59-3

Appearance

Oil

SMILES

CCCCCCCCCCCCCCCC(O[C@@]12[C@@]([C@@]3([H])[C@]([C@@H](C2)C)([C@@]4([H])[C@](CC(CO)=C3)(C(C(C)=C4)=O)O)O)([H])C1(C)C)=O

Structure Classification

Others

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (85.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7040 mL	8.5202 mL	17.0404 mL
5 mM	0.3408 mL	1.7040 mL	3.4081 mL
10 mM	0.1704 mL	0.8520 mL	1.7040 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. HuiYu Xu, et al. "12-Deoxyphorbol 13-palmitate mediated cell growth inhibition, G2-M cell cycle arrest and apoptosis in BGC823 cells." European journal of pharmacology 700.1-3 (2013): 13-22. [Content Brief]

[2]. Lu Gan, et al. "A natural small molecule alleviates liver fibrosis by targeting apolipoprotein L2." Nature Chemical Biology (2024): 1-11. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7040 mL	8.5202 mL	17.0404 mL	42.6010 mL
	5 mM	0.3408 mL	1.7040 mL	3.4081 mL	8.5202 mL
	10 mM	0.1704 mL	0.8520 mL	1.7040 mL	4.2601 mL
	15 mM	0.1136 mL	0.5680 mL	1.1360 mL	2.8401 mL
	20 mM	0.0852 mL	0.4260 mL	0.8520 mL	2.1301 mL
	25 mM	0.0682 mL	0.3408 mL	0.6816 mL	1.7040 mL
	30 mM	0.0568 mL	0.2840 mL	0.5680 mL	1.4200 mL
	40 mM	0.0426 mL	0.2130 mL	0.4260 mL	1.0650 mL
	50 mM	0.0341 mL	0.1704 mL	0.3408 mL	0.8520 mL
	60 mM	0.0284 mL	0.1420 mL	0.2840 mL	0.7100 mL
	80 mM	0.0213 mL	0.1065 mL	0.2130 mL	0.5325 mL