12-Deoxyphorbol 13-palmitate
Based on 1 Customer Validation
12-Deoxyphorbol 13-palmitate is a traditional Chinese medicine monomer with antitumor activity that can be isolated from the root of Euphorbia fischeriana. 12-Deoxyphorbol 13-palmitate induces gastric cancer cell cycle arrest and apoptosis by regulating key cell cycle regulators such as cyclin B、cyclin A and CDC2. In addition, 12-Deoxyphorbol 13-palmitate can significantly weaken APOL2–SERCA2–PERK–HES1 signaling and slow liver fibrosis by targeting APOL2.
For research use only. We do not sell to patients.
- Purity: 99.85%
- CAS No.: 66583-59-3
- Formula: C36H58O6
- Molecular Weight:586.84
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Natural Product Library
HY-L021
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Anti-Blood Cancer Compound Library
HY-L079
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Anti-Cancer Natural Product Library
HY-L107
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Plant-Sourced Natural Product Library
HY-L115
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Cell Death Library
HY-L162
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Anti-Hematopathy Compound Library
HY-L171
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Natural Product Library Plus
HY-L021P
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Natural Product and Natural Product-Like Compound Library
HY-L021M
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Bioactive Compound Library
HY-L001
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Anti-Gastric Cancer Compound Library
HY-L184
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Protein Kinase Compound Library
HY-L196
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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Cell Proliferation Compound Library
HY-L201
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High-Throughput Bioactive Compound Library
HY-L205
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High-Throughput Natural Product Library
HY-L206
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RNA Binding Bioactive Compound Library
HY-L248
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Mass Spectrometry Natural Product Library
HY-L262
Biological Activity
Chemical Information
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CAS No. 66583-59-3
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Appearance Oil
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Molecular Weight 586.84
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Formula C36H58O6
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Color Colorless to light yellow
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SMILES
CCCCCCCCCCCCCCCC(O[C@@]12[C@@]([C@@]3([H])[C@]([C@@H](C2)C)([C@@]4([H])[C@](CC(CO)=C3)(C(C(C)=C4)=O)O)O)([H])C1(C)C)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (85.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. HuiYu Xu, et al. "12-Deoxyphorbol 13-palmitate mediated cell growth inhibition, G2-M cell cycle arrest and apoptosis in BGC823 cells." European journal of pharmacology 700.1-3 (2013): 13-22. [Content Brief]
[2]. Lu Gan, et al. "A natural small molecule alleviates liver fibrosis by targeting apolipoprotein L2." Nature Chemical Biology (2024): 1-11. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7040 mL | 8.5202 mL | 17.0404 mL | 42.6010 mL |
| 5 mM | 0.3408 mL | 1.7040 mL | 3.4081 mL | 8.5202 mL | |
| 10 mM | 0.1704 mL | 0.8520 mL | 1.7040 mL | 4.2601 mL | |
| 15 mM | 0.1136 mL | 0.5680 mL | 1.1360 mL | 2.8401 mL | |
| 20 mM | 0.0852 mL | 0.4260 mL | 0.8520 mL | 2.1301 mL | |
| 25 mM | 0.0682 mL | 0.3408 mL | 0.6816 mL | 1.7040 mL | |
| 30 mM | 0.0568 mL | 0.2840 mL | 0.5680 mL | 1.4200 mL | |
| 40 mM | 0.0426 mL | 0.2130 mL | 0.4260 mL | 1.0650 mL | |
| 50 mM | 0.0341 mL | 0.1704 mL | 0.3408 mL | 0.8520 mL | |
| 60 mM | 0.0284 mL | 0.1420 mL | 0.2840 mL | 0.7100 mL | |
| 80 mM | 0.0213 mL | 0.1065 mL | 0.2130 mL | 0.5325 mL |
12-Deoxyphorbol 13-palmitate Related Classifications
HY-N13201 Related Classifications
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