66583-59-3
Chemical Structure
12-Deoxyphorbol 13-palmitate
- CAS No.: 66583-59-3
- Formula:C36H58O6
- Molecular Weight:586.84
InChIKey: QUVRUINWOFZNJL-IEIRSVMLSA-N
SMILES: CCCCCCCCCCCCCCCC(O[C@@]12[C@@]([C@@]3([H])[C@]([C@@H](C2)C)([C@@]4([H])[C@](CC(CO)=C3)(C(C(C)=C4)=O)O)O)([H])C1(C)C)=O
Biological Activity: 12-Deoxyphorbol 13-palmitate is a traditional Chinese medicine monomer with antitumor activity that can be isolated from the root of Euphorbia fischeriana. 12-Deoxyphorbol 13-palmitate induces gastric cancer cell cycle arrest and apoptosis by regulating key cell cycle regulators such as cyclin B、cyclin A and CDC2. In addition, 12-Deoxyphorbol 13-palmitate can significantly weaken APOL2–SERCA2–PERK–HES1 signaling and slow liver fibrosis by targeting APOL2[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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12-Deoxyphorbol 13-palmitate | 99.72% | 12-Deoxyphorbol 13-palmitate is a traditional Chinese medicine monomer with antitumor activity that can be isolated from the root of Euphorbia fischeriana. 12-Deoxyphorbol 13-palmitate induces gastric cancer cell cycle arrest and apoptosis by regulating key cell cycle regulators such as cyclin B、cyclin A and CDC2. In addition, 12-Deoxyphorbol 13-palmitate can significantly weaken APOL2–SERCA2–PERK–HES1 signaling and slow liver fibrosis by targeting APOL2. | ||||||||||||||||||||
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References
- [1]. HuiYu Xu, et al. "12-Deoxyphorbol 13-palmitate mediated cell growth inhibition, G2-M cell cycle arrest and apoptosis in BGC823 cells." European journal of pharmacology 700.1-3 (2013): 13-22. [Content Brief]
- [2]. Lu Gan, et al. "A natural small molecule alleviates liver fibrosis by targeting apolipoprotein L2." Nature Chemical Biology (2024): 1-11. [Content Brief]
