HSP90-IN-13
HSP90-IN-13 (compound 5k) is a highly potent HSP90 pan inhibitor with an IC50 value of 25.07 nM. HSP90-IN-13 has multi-target activity against EGFR, VEGFR-2 and Topoisomerase-2. HSP90-IN-13 causes cell cycle arrest at G2/M phase and induces apoptosis of MCF-7 cells through mitochondrial-mediated pathway.
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- No. CAS: 2446055-29-2
- Fòrmula: C26H21N5O3S
- Peso molecular:483.54
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Ver todos los productos específicos de isoformas Topoisomerase
MoreVer todos los productos específicos de isoformas EGFR
MoreVer todos los productos específicos de isoformas VEGFR
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
HSP90 25.07 nM (IC50) |
Topoisomerase-2 25.85 nM (IC50) |
EGFR 38.5 nM (IC50) |
VEGFR-2 126.95 nM (IC50) |
In Vitro
HSP90-IN-13 (compound 5k) arrests the cell cycle on MCF-7 at a G2/M phase by 35.06% and induced apoptosis by 19.82%[1].
HSP90-IN-13 has anti-proliferative activity against HCT-116, Hela and MCF-7 cell lines with IC50s of 4.47 μM, 7.55 μM and 4.04 μM, respectively[1].
HSP90-IN-13 has potent multi-target inhibitory activities against EGFR, VEGFR-2 and Topoisomerase-2 with IC50 values of 38.5 nM, 126.95 nM and 25.85 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2446055-29-2
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Peso molecular 483.54
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Fòrmula C26H21N5O3S
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SMILES
O=C(C1=CC=CC(N2N=NC(CSC3=NC4=C(C(N3CC5=CC=CC=C5)=O)C=C(C)C=C4)=C2)=C1)O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HSP90-IN-13 Related Classifications
HY-146228 Related Classifications
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