1. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Apoptosis JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  2. HSP Apoptosis Topoisomerase EGFR VEGFR
  3. HSP90-IN-13

HSP90-IN-13 (compound 5k) is a highly potent HSP90 pan inhibitor with an IC50 value of 25.07 nM. HSP90-IN-13 has multi-target activity against EGFR, VEGFR-2 and Topoisomerase-2. HSP90-IN-13 causes cell cycle arrest at G2/M phase and induces apoptosis of MCF-7 cells through mitochondrial-mediated pathway.

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HSP90-IN-13 Chemical Structure

HSP90-IN-13 Chemical Structure

CAS No. : 2446055-29-2

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Description

HSP90-IN-13 (compound 5k) is a highly potent HSP90 pan inhibitor with an IC50 value of 25.07 nM. HSP90-IN-13 has multi-target activity against EGFR, VEGFR-2 and Topoisomerase-2. HSP90-IN-13 causes cell cycle arrest at G2/M phase and induces apoptosis of MCF-7 cells through mitochondrial-mediated pathway[1].

IC50 & Target[1]

HSP90

25.07 nM (IC50)

Topoisomerase-2

25.85 nM (IC50)

EGFR

38.5 nM (IC50)

VEGFR-2

126.95 nM (IC50)

In Vitro

HSP90-IN-13 (compound 5k) arrests the cell cycle on MCF-7 at a G2/M phase by 35.06% and induced apoptosis by 19.82%[1].
HSP90-IN-13 has anti-proliferative activity against HCT-116, Hela and MCF-7 cell lines with IC50s of 4.47 μM, 7.55 μM and 4.04 μM, respectively[1].
HSP90-IN-13 has potent multi-target inhibitory activities against EGFR, VEGFR-2 and Topoisomerase-2 with IC50 values of 38.5 nM, 126.95 nM and 25.85 nM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

483.54

Formula

C26H21N5O3S

CAS No.
SMILES

O=C(C1=CC=CC(N2N=NC(CSC3=NC4=C(C(N3CC5=CC=CC=C5)=O)C=C(C)C=C4)=C2)=C1)O

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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HSP90-IN-13
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HY-146228
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