2446055-29-2
Chemical Structure
HSP90-IN-13
- CAS No.: 2446055-29-2
- Formula:C26H21N5O3S
- Molecular Weight:483.54
IUPAC Name: 3-(4-(((3-benzyl-6-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)thio)methyl)-1H-1,2,3-triazol-1-yl)benzoic acid
InChIKey: NSEFVZPTISOMAK-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CC(N2N=NC(CSC3=NC4=C(C(N3CC5=CC=CC=C5)=O)C=C(C)C=C4)=C2)=C1)O
Biological Activity: HSP90-IN-13 (compound 5k) is a highly potent HSP90 pan inhibitor with an IC50 value of 25.07 nM. HSP90-IN-13 has multi-target activity against EGFR, VEGFR-2 and Topoisomerase-2. HSP90-IN-13 causes cell cycle arrest at G2/M phase and induces apoptosis of MCF-7 cells through mitochondrial-mediated pathway[1].
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HSP90-IN-13 | HSP90-IN-13 (compound 5k) is a highly potent HSP90 pan inhibitor with an IC50 value of 25.07 nM. HSP90-IN-13 has multi-target activity against EGFR, VEGFR-2 and Topoisomerase-2. HSP90-IN-13 causes cell cycle arrest at G2/M phase and induces apoptosis of MCF-7 cells through mitochondrial-mediated pathway. | |||||||||||||||||||||
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Keywords
