Triphenyltin(IV) diisopropyl dithiocarbamate
Triphenyltin(IV) diisopropyl dithiocarbamate (Compound OC2) is an anti-leukemia agent. Triphenyltin(IV) diisopropyl dithiocarbamate exhibits extremely strong cytotoxicity towards Jurkat cells, with an IC₅₀ value of 0.1 μM. Triphenyltin(IV) diisopropyl dithiocarbamate causes DNA damage, which subsequently leads to mitochondrial dysfunction, a large amount of ROS production, and ultimately results in the activation of the mitochondrial apoptosis pathway (involving the activation of Caspase-9/-3) and the G0/G1 phase cell cycle arrest, all of which jointly lead to the death of leukemia cells.
For research use only. We do not sell to patients.
- Formula: C25H29NS2Sn
- Molecular Weight:526.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
Caspase 3 |
Caspase 9 |
Chemical Information
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Molecular Weight 526.34
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Formula C25H29NS2Sn
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SMILES
CC(C)N(C1=[S][Sn](C2=CC=CC=C2)(C3=CC=CC=C3)(C4=CC=CC=C4)S1)C(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Triphenyltin(IV) diisopropyl dithiocarbamate Related Classifications
HY-180782 Related Classifications
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