2. Metabolic Enzyme/Protease Anti-infection
  3. ATP Citrate Lyase Bacterial HIF/HIF Prolyl-Hydroxylase Endogenous Metabolite
  4. Lithium citrate tetrahydrate

Lithium citrate tetrahydrate  (Synonyms: Litarex tetrahydrate)

Cat. No.: HY-B1295 Purity: ≥98.0%
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Lithium citrate (Litarex) tetrahydrate is the major active ingredient of Garcinia cambogia. Lithium citrate tetrahydrate competitively inhibits ATP citrate lyase with weight loss benefits. Lithium citrate tetrahydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects.

For research use only. We do not sell to patients.

Lithium citrate tetrahydrate Chemical Structure

Lithium citrate tetrahydrate Chemical Structure

CAS No. : 6080-58-6

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
 USD 28 In-stock
Solution
10 mM * 1 mL in Water USD 28 In-stock
Solid
1 g USD 25 In-stock
5 g USD 45 In-stock
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Based on 2 publication(s) in Google Scholar

Other Forms of Lithium citrate tetrahydrate:

Lithium citrate tetrahydrate Related Antibodies

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2 Publications Citing Use of MCE Lithium citrate tetrahydrate

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Description

Lithium citrate (Litarex) tetrahydrate is the major active ingredient of Garcinia cambogia. Lithium citrate tetrahydrate competitively inhibits ATP citrate lyase with weight loss benefits. Lithium citrate tetrahydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects[1][2][3][4].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Lithium citrate tetrahydrate shows an HIF inhibitory effect compared with the control group in ARPE19 cells and 661W cells. Lithium citrate tetrahydrate can downregulate Hif1a and the downstream genes in ARPE19 cells and 661W cells. Lithium citrate tetrahydrate suppresses HIF-1α protein expression increased by CoCl2 administration in ARPE19 cells and 661W cells[2].
In chicken hepatocytes, Lithium citrate tetrahydrate decreases the accumulation of lipid droplets and accelerated energy metabolism. Lithium citrate tetrahydrate protects the cells from ER stress by increasing the antioxidant status and mitochondrial functions[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lithium citrate tetrahydrate Related Antibodies
In Vivo

Lithium citrate (100-200 mg/kg) tetrahydrate treatment could reduce markers of renal impairment (Blood Urea Nitrogen and serum creatinine). There is significantly less calcium oxalate crystal deposition in mice (male C57BL/6J mice) treated with Lithium citrate tetrahydrate. Lithium citrate tetrahydrate attenuates the oxidative stress induced by calcium oxalate crystallization. Lithium citrate tetrahydrate has inhibitory effects on calcium oxalate-induced inflammatory cytokines, such as MCP-1, IL-1 β, and IL-6. In addition, Lithium citrate tetrahydrate alleviates tubular injury and apoptosis caused by calcium oxalate crystals[1].
The administration of Lithium citrate tetrahydrate can suppress body weight gain and fat accumulation in animals[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

281.98

Formula

C6H13Li3O11
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(CC(C(O[Li])=O)(O)CC(O[Li])=O)O[Li].O.O.O.O
Structure Classification
Initial Source

Aspergillus niger
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (354.64 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5464 mL 17.7318 mL 35.4635 mL
5 mM 0.7093 mL 3.5464 mL 7.0927 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (177.32 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.5464 mL 17.7318 mL 35.4635 mL 88.6588 mL
5 mM 0.7093 mL 3.5464 mL 7.0927 mL 17.7318 mL
10 mM 0.3546 mL 1.7732 mL 3.5464 mL 8.8659 mL
15 mM 0.2364 mL 1.1821 mL 2.3642 mL 5.9106 mL
20 mM 0.1773 mL 0.8866 mL 1.7732 mL 4.4329 mL
25 mM 0.1419 mL 0.7093 mL 1.4185 mL 3.5464 mL
30 mM 0.1182 mL 0.5911 mL 1.1821 mL 2.9553 mL
40 mM 0.0887 mL 0.4433 mL 0.8866 mL 2.2165 mL
50 mM 0.0709 mL 0.3546 mL 0.7093 mL 1.7732 mL
60 mM 0.0591 mL 0.2955 mL 0.5911 mL 1.4776 mL
80 mM 0.0443 mL 0.2216 mL 0.4433 mL 1.1082 mL
100 mM 0.0355 mL 0.1773 mL 0.3546 mL 0.8866 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lithium citrate tetrahydrate6080-58-6Litarex tetrahydrateATP Citrate LyaseBacterialHIF/HIF Prolyl-HydroxylaseEndogenous MetaboliteACLYHypoxia-inducible factorsHIFsHIF-PHCitratecleavageextramitochondrialCaOxstonessafetyantioxidationanti-inflammationHIF-1αATPInhibitorinhibitorinhibit

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