2. MAPK/ERK Pathway Apoptosis
  3. MAP3K Apoptosis
  4. ASK1-IN-3

ASK1-IN-3 is a potent and selective ASK1 kinase inhibitor with IC50 of 33.8 nM, as well as inhibits several cell cycle regulating kinases. ASK1-IN-3 has strong HepG2 cancer cells apoptosis induction and potent cell cycle arrest activities.

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ASK1-IN-3 Chemical Structure

ASK1-IN-3 Chemical Structure

CAS No. : 2426705-19-1

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ASK1-IN-3 Related Antibodies

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Description

ASK1-IN-3 is a potent and selective ASK1 kinase inhibitor with IC50 of 33.8 nM, as well as inhibits several cell cycle regulating kinases. ASK1-IN-3 has strong HepG2 cancer cells apoptosis induction and potent cell cycle arrest activities[1].

IC50 & Target

IC50: 33.8 nM (ASK1)[1]
In Vitro

ASK1-IN-3 (compound 14l) (10, 20 and 50 μM; 48 hours) induces PARP cleavage in a dose dependent manner, which indicates the induction of HepG2 cells apoptosis[1].
ASK1-IN-3 (1-16 μM; 24 hours) significantly arrests cycle progression at G1 phase[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ASK1-IN-3 Related Antibodies

Apoptosis Analysis

Cell Line: HepG2[1]
Concentration: 10, 20 and 50 μM
Incubation Time: 48 hours
Result: Induced PARP cleavage in a dose dependent manner.

Cell Cycle Analysis

Cell Line: HepG2[1]
Concentration: 1, 2, 4, 8, and 16 μM
Incubation Time: 24 hours
Result: Significantly arrested cycle progression at G1 phase.
Molecular Weight

378.39

Formula

C18H18N8O2
CAS No.
SMILES

C[C@@H](N1C=NN=C1C2=NC(NC(NC3=NN4C=CC=CC4=C3)=O)=CC=C2)CO
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ASK1-IN-3 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ASK1-IN-32426705-19-1MAP3KApoptosisMAP kinase kinase kinase, MEKK, MAPKKKASKCell cycleCancerNonalcoholic steatohepatitisHepG2Inhibitorinhibitorinhibit

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