1. MAPK/ERK Pathway
    Apoptosis
  2. MAP3K
    Apoptosis
  3. ASK1-IN-3

ASK1-IN-3 

Cat. No.: HY-146729
Handling Instructions

ASK1-IN-3 is a potent and selective ASK1 kinase inhibitor with IC50 of 33.8 nM, as well as inhibits several cell cycle regulating kinases. ASK1-IN-3 has strong HepG2 cancer cells apoptosis induction and potent cell cycle arrest activities.

For research use only. We do not sell to patients.

ASK1-IN-3 Chemical Structure

ASK1-IN-3 Chemical Structure

CAS No. : 2426705-19-1

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Description

ASK1-IN-3 is a potent and selective ASK1 kinase inhibitor with IC50 of 33.8 nM, as well as inhibits several cell cycle regulating kinases. ASK1-IN-3 has strong HepG2 cancer cells apoptosis induction and potent cell cycle arrest activities[1].

IC50 & Target

IC50: 33.8 nM (ASK1)[1]

In Vitro

ASK1-IN-3 (compound 14l) (10, 20 and 50 μM; 48 hours) induces PARP cleavage in a dose dependent manner, which indicates the induction of HepG2 cells apoptosis[1].
ASK1-IN-3 (1-16 μM; 24 hours) significantly arrests cycle progression at G1 phase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis

Cell Line: HepG2[1]
Concentration: 10, 20 and 50 μM
Incubation Time: 48 hours
Result: Induced PARP cleavage in a dose dependent manner.

Cell Cycle Analysis

Cell Line: HepG2[1]
Concentration: 1, 2, 4, 8, and 16 μM
Incubation Time: 24 hours
Result: Significantly arrested cycle progression at G1 phase.
Molecular Weight

378.39

Formula

C18H18N8O2

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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ASK1-IN-3
Cat. No.:
HY-146729
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