2426705-19-1
2426705-19-1
Chemical Structure
ASK1-IN-3
- CAS No.: 2426705-19-1
- Formula:C18H18N8O2
- Molecular Weight:378.39
IUPAC Name: (R)-1-(6-(4-(1-hydroxypropan-2-yl)-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-3-(pyrazolo[1,5-a]pyridin-2-yl)urea
InChIKey: GSYUZRLLPWNNAL-GFCCVEGCSA-N
SMILES: C[C@@H](N1C=NN=C1C2=NC(NC(NC3=NN4C=CC=CC4=C3)=O)=CC=C2)CO
Biological Activity: ASK1-IN-3 is a potent and selective ASK1 kinase inhibitor with IC50 of 33.8 nM, as well as inhibits several cell cycle regulating kinases. ASK1-IN-3 has strong HepG2 cancer cells apoptosis induction and potent cell cycle arrest activities[1].
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ASK1-IN-3 | ASK1-IN-3 is a potent and selective ASK1 kinase inhibitor with IC50 of 33.8 nM, as well as inhibits several cell cycle regulating kinases. ASK1-IN-3 has strong HepG2 cancer cells apoptosis induction and potent cell cycle arrest activities. | |||||||||||||||||||||
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