Quinacrine mustard dihydrochloride
Based on 2 publication(s) in Google Scholar
Quinacrine mustard dihydrochloride is a fluorochrome. Quinacrine mustard dihydrochloride as a polycyclic aromatic agent can be used as mutagenic agent induces the mutants of bacteria. Quinacrine mustard dihydrochloride induces cell cycle arrest at G2/M-phase. Quinacrine mustard dihydrochloride has the potential for the research of plant, animal, or human chromosomes.
For research use only. We do not sell to patients.
- Purity: 95.99%
- CAS No.: 4213-45-0
- Formula: C23H30Cl5N3O
- Molecular Weight:541.77
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Quinacrine mustard dihydrochloride
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Biological Activity
Quinacrine mustard dihydrochloride (5 μg/mL) can be used for the DNA strain of plant, animal, or human chromosomes[1].
Quinacrine mustard dihydrochloride (28 μM) increases the number of
mutants that appeared after an exposure of bacteria[2].
quinacrine mustard dihydrochloride (0.2 μM; 4h) induces cell cycle arrest at G2+M-phase in HL-60 cells[3].
Caffeine (5 mM) prevents the cytotoxic action of quinacrine mustard dihydrochloride (0.2 μM; 4h) in HL-60 cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HL-60 cells
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Concentration:0.2 µM
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Incubation Time:4 h
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Result:Induced cell cycle arrest at G2+M-phase with the accumulation of cells in this compartment by 50%.
Chemical Information
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CAS No. 4213-45-0
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Appearance Solid
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Molecular Weight 541.77
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Formula C23H30Cl5N3O
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Color Light yellow to yellow
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SMILES
CC(CCCN(CCCl)CCCl)N=C1C2=C(C=C(C=C2)Cl)NC3=C1C=C(C=C3)OC.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (2)
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Journal Impact Factor
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Most Recent
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ACS Nano
Nanoenabled Disruption of Multiple Barriers in Antigen Cross-Presentation of Dendritic Cells via Calcium Interference for Enhanced Chemo-Immunotherapy. [Abstract]2020 Jun 23;14(6):7639-7650. PMID: 32427462 -
Pigment Cell Melanoma Res
2025 Sep;38(5):e70048. PMID: 40913269
Solvent & Solubility
DMSO : 25 mg/mL (46.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 6.25 mg/mL (11.54 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (645 KB)
- English - EN (645 KB)
- Français - FR (645 KB)
- Deutsch - DE (645 KB)
- Norwegian - NO (645 KB)
- Español - ES (645 KB)
- Swedish - SV (645 KB)
- Italian - IT (645 KB)
- Korean - KR (645 KB)
- Portuguese - PT (645 KB)
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Handling Instructions (2659 KB)
References
[1]. Caspersson T, et al. Fluorescent labeling of chromosomal DNA: superiority of quinacrine mustard to quinacrine. Science. 1970 Nov 13;170(3959):762. [Content Brief]
[2]. Piosik J, et al. Alleviation of mutagenic effects of polycyclic aromatic agents (quinacrine mustard, ICR-191 and ICR-170) by caffeine and pentoxifylline. Mutat Res. 2003 Sep 29;530(1-2):47-57. [Content Brief]
[3]. Kapuscinski J, et al. The modulation of the DNA-damaging effect of polycyclic aromatic agents by xanthines. Part I. Reduction of cytostatic effects of quinacrine mustard by caffeine. Biochem Pharmacol. 2002 Feb 15;63(4):625-34. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.8458 mL | 9.2290 mL | 18.4580 mL | 46.1450 mL |
| 5 mM | 0.3692 mL | 1.8458 mL | 3.6916 mL | 9.2290 mL | |
| 10 mM | 0.1846 mL | 0.9229 mL | 1.8458 mL | 4.6145 mL | |
| DMSO | 15 mM | 0.1231 mL | 0.6153 mL | 1.2305 mL | 3.0763 mL |
| 20 mM | 0.0923 mL | 0.4615 mL | 0.9229 mL | 2.3073 mL | |
| 25 mM | 0.0738 mL | 0.3692 mL | 0.7383 mL | 1.8458 mL | |
| 30 mM | 0.0615 mL | 0.3076 mL | 0.6153 mL | 1.5382 mL | |
| 40 mM | 0.0461 mL | 0.2307 mL | 0.4615 mL | 1.1536 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Quinacrine mustard dihydrochloride Related Classifications
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