Naratuximab emtansine
Naratuximab emtansine (IMGN529) is a CD37-targeted ADC consisting of a humanized IgG1 mAb coupled to the microtubule disruptor DM1. Naratuximab emtansine has high affinity and specificity for CD37, allowing ADC internalization, processing and intracellular release of DM1. Due to its ability to disrupt microtubule assembly, DM1 can subsequently induce cell cycle arrest and apoptosis.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Antibody:
- Linker-Payload:
- CAS. Nr.: 1607824-64-5
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Speicherung:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
Naratuximab emtansine (IMGN529) (0.125 nM, 24 h) treatment alone induces activation of cystein 3/7 in DLBCL cell lines and this effect is significantly enhanced in the presence of rituximab (2 nM), which further induces an increase in cleaved PARP levels[1].
Naratuximab emtansine (IMGN529) (0-3 ng/mL) shows dose-dependent antibody-dependent cell-mediated cytotoxicity (ADCC) activity against U-2932 and SU-DHL-4 cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Product Details
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Antibody
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Linker-Payload
Chemical Information
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CAS. Nr. 1607824-64-5
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Appearance Liquid
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Color Colorless to light yellow
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SMILES
[Naratuximab emtansine]
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Synonyms
IMGN529; Debio 1562
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Versand
Shipping with dry ice.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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