Naratuximab emtansine
Based on 1 Customer Validation
Naratuximab emtansine (IMGN529) is a CD37-targeted ADC consisting of a humanized IgG1 mAb coupled to the microtubule disruptor DM1. Naratuximab emtansine has high affinity and specificity for CD37, allowing ADC internalization, processing and intracellular release of DM1. Due to its ability to disrupt microtubule assembly, DM1 can subsequently induce cell cycle arrest and apoptosis.
For research use only. We do not sell to patients.
- Purity: 98.52%
- CAS No.: 1607824-64-5
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Naratuximab emtansine (IMGN529) (0.125 nM, 24 h) treatment alone induces activation of cystein 3/7 in DLBCL cell lines and this effect is significantly enhanced in the presence of rituximab (2 nM), which further induces an increase in cleaved PARP levels[1].
Naratuximab emtansine (IMGN529) (0-3 ng/mL) shows dose-dependent antibody-dependent cell-mediated cytotoxicity (ADCC) activity against U-2932 and SU-DHL-4 cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1607824-64-5
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Appearance Liquid
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Color Colorless to light yellow
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SMILES
[Naratuximab emtansine]
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Synonyms
IMGN529; Debio 1562
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Shipping
Shipping with dry ice.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (256 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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