Naratuximab
Based on 1 publication(s) in Google Scholar
Naratuximab (Anti-TSPAN26/CD37 Reference Antibody (naratuximab)) is a humanized monoclonal antibody that binds CD37 (TSPAN26). Naratuximab can be used to synthesize an ADC compound, Naratuximab emtansine.
For research use only. We do not sell to patients.
- Purity: 99.9%
- CAS No.: 1622327-39-2
- Molecular Weight:143.6 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) Naratuximab
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Biological Activity
Human IgG1 kappa
Human
TSPAN26/CD37
Naratuximab emtansine (IMGN529), an ADC comprised of DM1 linked to a humanized anti-CD37 antibody via the same linker used in Kadcyla. Naratuximab emtansine effectively combines the intrinsic proapoptotic and effector activities of its antibody component with the cytotoxic activity of the maytansinoid payload[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 kappa
ELISA, FACS, Functional assay
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Immobilized hu-CD37-VLP can bind Naratuximab. The EC50 for this effect is 4.061 ng/mL. -
Flow Cytometry analysis of Raji cells labelling CD37 (red) with Naratuximab (anti-CD37) (HY-P99374). Goat Anti-Human IgG (FITC) (ZF-0308) at a dilution of 1/100 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody.
Chemical Information
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CAS No. 1622327-39-2
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Appearance Liquid
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Molecular Weight 143.6 kDa
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Color Colorless to light yellow
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SMILES
[Naratuximab]
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Synonyms
Anti-TSPAN26/CD37 Reference Antibody (naratuximab)
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Nat Commun
Targeting CD37 promotes macrophage-dependent phagocytosis of multiple cancer cell types and facilitates tumor clearance in mice. [Abstract]2025 Jul 18;16(1):6610. PMID: 40675974
Purity & Documentation
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Data Sheet (257 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)