CD37 - CD37 molecule Gene

Also Known as GP52-40; TSPAN26

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 951

About CD37

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,335,406-49,340,606 (from NCBI)

This gene has 15 transcripts (splice variants), 132 orthologues and 32 paralogues. Biased expression in lymph node (RPKM 111.7), spleen (RPKM 99.3) and 8 other tissues.

Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and Other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

CD37 Products (2)

mRNA Protein Name
NM_001040031.2 NP_001035120.1 leukocyte antigen CD37 isoform B
NM_001774.3 NP_001765.1 leukocyte antigen CD37 isoform A

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21930792 GOA
Cellular Component GO Annotation Evidence References Source
located in immunological synapse IDA
IDA: Inferred from direct assay
21930792 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD37 Protein Structure

Tetraspannin

Tetraspannin: Tetraspanin family (11 - 269)

  • 0
  • 100
  • 200
  • 281 a.a.
Protein Preferred Names Protein Names

leukocyte antigen CD37

  • cell differentiation antigen 37

CD37 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CD37 P11049 GJB1 Homo sapiens P08034
Y2H Prey Pooling
32296183
Intra
CD37 P11049 GJB1 Homo sapiens P08034
Y2H Array
32296183
Intra
CD37 P11049 LRRC3B Homo sapiens Q96PB8
Validated Y2H
32296183
Intra
CD37 P11049 LRRC3B Homo sapiens Q96PB8
Y2H Prey Pooling
32296183
Intra
CD37 P11049 LRRC3B Homo sapiens Q96PB8
Y2H Array
32296183
Intra
CD37 P11049 LHFPL5 Homo sapiens Q8TAF8
Y2H Prey Pooling
32296183
Intra
CD37 P11049 LHFPL5 Homo sapiens Q8TAF8
Validated Y2H
32296183
Intra
CD37 P11049 LHFPL5 Homo sapiens Q8TAF8
Y2H Array
32296183
Intra
CD37 P11049 EMP1 Homo sapiens P54849
Y2H Prey Pooling
32296183
Intra
CD37 P11049 EMP1 Homo sapiens P54849
Validated Y2H
32296183
Intra
CD37 P11049 EMP1 Homo sapiens P54849
Y2H Array
32296183
Intra
CD37 P11049 CD53 Homo sapiens P19397
Validated Y2H
32296183
Intra
CD37 P11049 CD53 Homo sapiens P19397
Y2H Array
32296183
Intra
CD37 P11049 CD53 Homo sapiens P19397
Y2H Prey Pooling
32296183
Intra
CD37 P11049 PTPN6 Homo sapiens P29350
Anti Bait CoIP
22624718
Intra
CD37 P11049 SYK Homo sapiens P43405
Anti Bait CoIP
22624718
Intra
CD37 P11049 LYN Homo sapiens P07948
Anti Bait CoIP
22624718
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD37 Proteins

Cat. No. Product Name Accession Purity
HY-P77886 CD37 Protein, Human (HEK293, Fc) P11049 (A113-N240) ≥ 95%, as determined by Bis-Tris PAGE.

CD37 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81648 CD37 Antibody (YA1393) FC, ELISA Human
HY-P85089 CD37 Antibody (YA4781) ICC/IF, ELISA Human, Mouse

Related Diseases

Diseases Alias
High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit

  • Hgbl-Dh/Th

  • High Grade B-Cell Lymphoma With Myc And Bcl2 Or Bcl6 Rearrangements

  • High Grade B-Cell Lymphoma With Myc And/ Or Bcl2 And/Or Bcl6 Rearrangement
Osteogenesis Imperfecta, Type Iii

  • Osteogenesis Imperfecta Type Iii

  • OI3

  • Oi, Type Iii

  • Osteogenesis Imperfecta Type 3

  • Oi Type Iii

  • Oi Type 3

  • Progressive Deforming Osteogenesis Imperfecta

  • Severe Osteogenesis Imperfecta

  • Osteogenesis Imperfecta, Progressively Deforming, With Normal Sclerae

  • Progressively Deforming Osteogenesis Imperfecta With Normal Sclera

  • Osteogenesis Imperfecta, Progressively Deforming With Normal Sclerae

  • Progressively Deforming Oi

  • Osteogenesis Imperfecta 3

  • Oi-Iii

  • Progressively Deforming Osteogenesis Imperfecta With Normal Sclerae
Mantle Cell Lymphoma

  • Lymphoma, Mantle Cell

  • Lcm

  • Mcl

  • Mantle Zone Lymphoma

  • Lymphoma Mantle-Cell

  • Lymphoma, Mantle-Cell

  • Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse

  • Malignant Lymphoma - Lymphocytic, Intermediate Differentiation

  • Diffuse Small Cleaved-Cell Lymphoma

  • Diffuse Small Cleaved Cell Malignant Lymphoma

  • Small Cleaved Cell Non-Hodgkin Lymphoma

  • Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma

  • Malignant Lymphomatous Polyposis

  • Malignant Small Cell, Noncleaved, Diffuse Lymphoma

  • Malignant Undifferentiated Cell, Non-Burkitt Lymphoma

  • Cleaved Cell Lymphoma

  • Small Cell Mantle Cell Lymphoma

  • Small Cleaved Cell Malignant Lymphoma
Leukemia, Chronic Lymphocytic

  • Chronic Lymphocytic Leukemia

  • B-Cell Chronic Lymphocytic Leukemia

  • CLL

  • B-Cell Chronic Lymphoid Leukemia

  • Chronic Lymphatic Leukemia

  • Chronic Lymphocytic Leukaemia

  • Lymphoplasmacytic Leukemia

  • Small Lymphocytic Lymphoma

  • Leukemia, Chronic Lymphatic

  • B-Cell Chronic Lymphocytic Leukaemia

  • Chronic Lymphatic Leukaemia

  • Lymphoplasmacytic Leukaemia

  • B Cell Chronic Lymphocytic Leukemia

  • Chronic B-Cell Lymphocytic Leukemia

  • Leukemia, Lymphocytic, Chronic

  • B-Cll

  • Chronic Lymphoid Leukemia

  • Leukemia Lymphocytic Chronic

  • Lymphoma Small Lymphocytic

  • Leukemia, Lymphocytic, Chronic, B-Cell
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (4)
Cat. No. Product Name Effect
Purity Phase
HY-132260 Naratuximab emtansine Inducer 98.52% Phase 2
HY-P99674 Ivicentamab Inhibitor 99.82% Phase 2
HY-P99707 Lilotomab Inducer 98.99% Phase 2
HY-P990317 AGS-67E Inhibitor 99.46% Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02238 CD37 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17365 Cd37 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23819 Cd37 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99374 Naratuximab 99.9% Unkown
HY-P991523 BI-836826 Inducer / Unkown
HY-P991912 PSB107 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CD37 VGNC VGNC:70761
Canis familiaris CD37 VGNC VGNC:38952
Felis catus CD37 VGNC VGNC:60615
Mus musculus CD37 MGD MGI:88330
Rattus norvegicus CD37 RGD RGD:62035
Bos taurus CD37 VGNC VGNC:27026
Others CD37 NCBI