CD37 Antibody (YA1393)
(Synonyms: CD37; TSPAN26; Leukocyte antigen CD37; Tetraspanin-26; Tspan-26; CD37)CD37 Antibody (YA1393) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD37.
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Host:
Rabbit
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Isotype:
IgG
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Application:
FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Conjugation:
Non-conjugated
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Applications
| Application |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:50-1:100 | 1:10000 |
Product Details
CD37 Antibody (YA1393) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD37.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 32 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 32 kDa
Recombinant human CD37 protein
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD37 is a Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Upon ligand binding, two signaling pathways are activated, one acting through phosphorylation by LYN leading to cell death or a survival pathway with activation of GSK3B. Plays an essential role essential for clustering of integrin ITGA4/ITGB1 and promotes its mobility in the plasma membrane of B-cells. In turn, participates in ITGA4/ITGB1 integrin-mediated antiapoptotic signaling through AKT. Also plays a role in the migration of dendritic cells and neutrophils to draining lymph nodes, as well as in their integrin-mediated adhesion. Negatively regulates IL-6 responses through direct interaction with SOCS3 thereby preventing constitutive IL-6 signaling. Alternatively, inhibition of IL-6 signaling can also occur via interaction and stabilization of DECTIN1/CLEC7A at the cell membrane to inhibit its ability to promote the production of IL-6[1][2][3].
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Subcellular Localization
Cell membrane; Multi-pass membrane protein
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Expression
Tissue_specificity:B lymphocytes (PubMed: 26784544) . Antigen-presenting cells (PubMed: 17182550) . -
Isoforms & Post-Translational Modification
P11049 has 3 isomers: P11049-1: 31703 Da (predicted); P11049-2: 23996 Da (predicted); P11049-3: 22563 Da (predicted).
Tyrosine phosphorylated; leading to activation of downstream signaling pathways -
Subunit
Interacts with SCIMP (PubMed:21930792). Interacts with SOCS3 (PubMed:26784544). Interacts with DECTIN1/CLEC7A (PubMed:17182550)
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SwissProt ID
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Synonyms
CD37; TSPAN26; Leukocyte antigen CD37; Tetraspanin-26; Tspan-26; CD37
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Research Field
Immunology
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