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  5. CD37 Antibody (YA1393)

CD37 Antibody (YA1393) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD37.

For research use only. We do not sell to patients.

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100 μL   Get quote  

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

CD37 Antibody (YA1393) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD37.
Host

Rabbit
Clonality

Recombinant, Monoclonal
Molecular Weight
Predicted band size: 32 kDa;
Observed band size: 32 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

Recombinant human CD37 protein
Application &
Dilution Ratio
Application Dilution Ratio
FC
FC: Flow Cytometry
1:50-1:100
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
1:10000
Sensitivity Endogenous Purity Affinity Chromatography
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking (PubMed:22624718). Upon ligand binding, two signaling pathways are activated, one acting through phosphorylation by LYN leading to cell death or a survival pathway with activation of GSK3B (PubMed:22624718). Plays an essential role essential for clustering of integrin ITGA4/ITGB1 and promotes its mobility in the plasma membrane of B-cells. In turn, participates in ITGA4/ITGB1 integrin-mediated antiapoptotic signaling through AKT (By similarity). Also plays a role in the migration of dendritic cells and neutrophils to draining lymph nodes, as well as in their integrin-mediated adhesion (By similarity). Negatively regulates IL-6 responses through direct interaction with SOCS3 thereby preventing constitutive IL-6 signaling (PubMed:26784544). Alternatively, inhibition of IL-6 signaling can also occur via interaction and stabilization of DECTIN1/CLEC7A at the cell membrane to inhibit its ability to promote the production of IL-6 (PubMed:17182550)
Subcellular Localization：Cell membrane; Multi-pass membrane protein
Expression：
Tissue_specificity:B lymphocytes (PubMed: 26784544) . Antigen-presenting cells (PubMed: 17182550) .
Isoforms & Post-Translational Modification：P11049 has 3 isomers: P11049-1: 31703 Da (predicted); P11049-2: 23996 Da (predicted); P11049-3: 22563 Da (predicted).
Tyrosine phosphorylated; leading to activation of downstream signaling pathways
Subunit：Interacts with SCIMP (PubMed:21930792). Interacts with SOCS3 (PubMed:26784544). Interacts with DECTIN1/CLEC7A (PubMed:17182550)
Database

Entrez Gene: 951 Human

SwissProt: P11049 Human

OMIM: 151523 Human

Research Field

Immunology
Synonyms
CD37; TSPAN26; Leukocyte antigen CD37; Tetraspanin-26; Tspan-26; CD37
Documentation
User Guide for Antibodies (1077 KB)

CD37 Antibody (YA1393) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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CD37 Antibody (YA1393)
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HY-P81648
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