CD37 Antibody (YA4781)

Cat. No.: HY-P85089: Data Sheet User Guide for Antibodies
FAQs
Technical Support

CD37 Antibody (YA4781) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD37.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

* Please select Quantity before adding items.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

CD37 Antibody (YA4781) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD37.

Host

Mouse

Clonality

Monoclonal

Species Reactivity

Human, Mouse

SwissProt ID

P11049

Gene ID

951 [NCBI]

Immunogen

Purified recombinant fragment of CD37 expressed in E. Coli.

Application &
Dilution Ratio

Application	Dilution Ratio
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:200-1:1000
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified

Appearance

Liquid

Formulation

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking (PubMed:22624718). Upon ligand binding, two signaling pathways are activated, one acting through phosphorylation by LYN leading to cell death or a survival pathway with activation of GSK3B (PubMed:22624718). Plays an essential role essential for clustering of integrin ITGA4/ITGB1 and promotes its mobility in the plasma membrane of B-cells. In turn, participates in ITGA4/ITGB1 integrin-mediated antiapoptotic signaling through AKT (By similarity). Also plays a role in the migration of dendritic cells and neutrophils to draining lymph nodes, as well as in their integrin-mediated adhesion (By similarity). Negatively regulates IL-6 responses through direct interaction with SOCS3 thereby preventing constitutive IL-6 signaling (PubMed:26784544). Alternatively, inhibition of IL-6 signaling can also occur via interaction and stabilization of DECTIN1/CLEC7A at the cell membrane to inhibit its ability to promote the production of IL-6 (PubMed:17182550)

Subcellular Localization：Cell membrane; Multi-pass membrane protein

Expression：
Tissue_specificity:B lymphocytes (PubMed: 26784544) . Antigen-presenting cells (PubMed: 17182550) .

Isoforms & Post-Translational Modification：P11049 has 3 isomers: P11049-1: 31703 Da (predicted); P11049-2: 23996 Da (predicted); P11049-3: 22563 Da (predicted).
Tyrosine phosphorylated; leading to activation of downstream signaling pathways

Subunit：Interacts with SCIMP (PubMed:21930792). Interacts with SOCS3 (PubMed:26784544). Interacts with DECTIN1/CLEC7A (PubMed:17182550)

Synonyms

CD37; TSPAN26; Leukocyte antigen CD37; Tetraspanin-26; Tspan-26; CD antigen CD37

Documentation

User Guide for Antibodies (1077 KB)