EGFR/VEGFR2-IN-13
EGFR/VEGFR2-IN-13 is a multi-target inhibitor, with an IC50 of 0.98 µM against VEGFR-2, 1.01 µM against EGFR, and 1.94 µM against topoisomerase II. EGFR/VEGFR2-IN-13 induces cell cycle arrest and apoptosis in tumor cells. As an anticancer agent, EGFR/VEGFR2-IN-13 exhibits cytotoxicity against cancer cells. EGFR/VEGFR2-IN-13 can be used in research related to breast cancer, colon cancer, and liver cancer.
For research use only. We do not sell to patients.
- Formula: C24H28N4O4S2
- Molecular Weight:500.63
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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VEGFR-2 |
Topoisomerase II |
EGFR/VEGFR2-IN-13 (compound 16) inhibits the proliferation of MCF-7, HCT-116 and HepG-2 cancer cell lines after 48 h, with IC50 values of 3.78 µM, 4.27 µM and 4.79 µM, respectively[1].
EGFR/VEGFR2-IN-13 (3.78 µM; 72 h) induces apoptosis as the primary mode of cell death in MCF-7 cells[1].
EGFR/VEGFR2-IN-13 (3.78 µM; 72 h) induces G0/G1 cell cycle arrest in MCF-7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7
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Concentration:3.78 µM
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Incubation Time:72 h
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Result:Induced a total apoptosis rate of 32.79% (19.39% early apoptotic cells, 8.33% late apoptotic cells) and a necrosis rate of 5.07%, compared to 3.12% total apoptosis and 2.34% necrosis in untreated control cells.
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Cell Line:MCF-7
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Concentration:3.78 µM
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Incubation Time:72 h
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Result:Resulted in accumulation of 65.88% of cells in the G0/G1 phase, 29.67% in the S phase, and 4.43% in the G2/M phase.
Chemical Information
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Molecular Weight 500.63
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Formula C24H28N4O4S2
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SMILES
O=C1N(C2=CC=C(OC)C=C2)/C(SC1)=N\N=C(C3=CC=C(S(=O)(N4CC(C)CCC4)=O)C=C3)/C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR/VEGFR2-IN-13 Related Classifications
HY-183090 Related Classifications
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