FGFR1 inhibitor-6
FGFR1 inhibitor-6 is a potent FGFR1 inhibitor with an IC50 value of 16.31 nM. FGFR1 inhibitor-6 shows cytotoxic activities. FGFR1 inhibitor-6 induces apoptosis and cell cycle arrest at pre-G1 and G2/M phase.
For research use only. We do not sell to patients.
- Formula: C27H19N5O4S2
- Molecular Weight:541.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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FGFR1 16.31 nM (IC50) |
FGFR1 inhibitor-6 (compound 3) (48 h) shows cytotoxic activities with IC50s of 2.06, 0.73, 97.2 µM for HepG-2, MCF-7, WI-38 cells, respectively[1].
FGFR1 inhibitor-6 (0.73 µM; 24 h) induces apoptosis and cell cycle arrest at pre-G1 and G2/M phase[1].
FGFR1 inhibitor-6 (0.73 µM; 24 h) increases the expression of caspase-3/7/9 protein levels in MCF-7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG-2, MCF-7, WI-38 cells
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Concentration:
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Incubation Time:48 h
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Result:Showed cytotoxic activities with IC50s of 2.06, 0.73, 97.2 µM for HepG-2, MCF-7, WI-38 cells, respectively.
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Cell Line:MCF-7 cells
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Concentration:0.73 µM
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Incubation Time:24 h
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Result:Induced pronounced increase in the cell percentages at pre-G1 and G2/M phase at 27.72% and 19.22%, respectively.
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Cell Line:MCF-7 cells
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Concentration:0.73 µM
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Incubation Time:24 h
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Result:Induced apoptosis with late apoptosis percentages are 11.24 % and the early apoptosis percentages from 1.59% to 5.07%.
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Cell Line:MCF-7 cells
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Concentration:0.73 µM
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Incubation Time:24 h
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Result:Increased the expression of caspase-3/7/9 protein levels with the caspase-3, aspase-7, aspase-9 protein levels increased to 5.60, 11.62, 7.14 folds, respectively comparing with the untreated cells.
Chemical Information
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Molecular Weight 541.60
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Formula C27H19N5O4S2
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SMILES
COC1=CC(C2=NC3=CC=CC=C3S2)=CC=C1OCC(N/N=C4NC(/C(S/4)=C/C5=CC=C(C=C5)C#N)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FGFR1 inhibitor-6 Related Classifications
HY-143272 Related Classifications
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