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Top/HDAC-IN-1

Top/HDAC-IN-1 (Compound 29b) is a topoisomerase/HDAC dual inhibitor with IC50s of 18, 230, 790, 87, and 5250 nM for HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8, respectively. Top/HDAC-IN-1 exhibits potent antitumor activities against the HCT116 cell line with the IC50 of 180 nM. Top/HDAC-IN-1 efficiently induces apoptosis with G2 cell cycle arrest in HCT116 cells.

For research use only. We do not sell to patients.

  • CAS No.: 2775446-49-4
  • Formula: C29H27N5O4
  • Molecular Weight:509.56
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Top/HDAC-IN-1 Chemical Structure
    Top/HDAC-IN-1 Chemical Structure
CAS No.: 2775446-49-4
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Top Publications Citing

Use of MCE Products

All HDAC Isoforms

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All Topoisomerase Isoforms

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100 mg

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  • Top/HDAC-IN-1 Chemical Structure
    Top/HDAC-IN-1 Chemical Structure
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  • Top/HDAC-IN-1