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Cat. No.: HY-145851

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Top/HDAC-IN-1

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Top/HDAC-IN-1 (Compound 29b) is a topoisomerase/HDAC dual inhibitor with IC₅₀s of 18, 230, 790, 87, and 5250 nM for HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8, respectively. Top/HDAC-IN-1 exhibits potent antitumor activities against the HCT116 cell line with the IC₅₀ of 180 nM. Top/HDAC-IN-1 efficiently induces apoptosis with G2 cell cycle arrest in HCT116 cells.

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CAS No.: 2775446-49-4
Formule: C₂₉H₂₇N₅O₄
Masse moléculaire:509.56

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Data Sheet (264 KB)

Top/HDAC-IN-1 Chemical Structure

CAS No.: 2775446-49-4

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Activité biologique
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- Cellular Effect
Chemical Information
Publications (1)
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform HDAC :

Voir tous les produits spécifiques à Isoform Topoisomerase :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.18 μM Compound: 16a	Antiproliferative activity against human A549 cells Antiproliferative activity against human A549 cells	[PMID: 37875056]
HCT-116	IC₅₀	0.18 μM Compound: 16a	Antiproliferative activity against human HCT-116 cells Antiproliferative activity against human HCT-116 cells	[PMID: 37875056]
HCT-116	IC₅₀	0.18 μM Compound: 70	Antiproliferative activity against human HCT-116 cells Antiproliferative activity against human HCT-116 cells	[PMID: 36549115]
MCF7	IC₅₀	0.18 μM Compound: 16a	Antiproliferative activity against human MCF7 cells Antiproliferative activity against human MCF7 cells	[PMID: 37875056]

Chemical Information

CAS No. 2775446-49-4
Masse moléculaire 509.56
Formule C₂₉H₂₇N₅O₄
SMILES

CN1C2=C(C(N3CCC4=C(C13)NC5=C4C=C(C=C5)O)=O)C=C(C=C2)NCC6=CC=C(C=C6)/C=C/C(NO)=O
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Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

Int J Parasitol Drugs Drug Resist

2026 May 17;31:100649.

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Fugui Zhu, et al. Design, Synthesis, and Structure-Activity relationships of Evodiamine-Based topoisomerase (Top)/Histone deacetylase (HDAC) dual inhibitors. Bioorg Chem. 2022 May;122:105702. [Content Brief]

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Keywords

Top/HDAC-IN-1

1 Cited Publications

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Top/HDAC-IN-1

Publications Citing Use of MedChemExpress (MCE) Top/HDAC-IN-1

Voir tous les produits spécifiques à Isoform HDAC

Voir tous les produits spécifiques à Isoform Topoisomerase

Activité biologique

Chemical Information

Publications (1)

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Top/HDAC-IN-1 Related Classifications

HY-145851 Related Classifications