Isocannflavin B
Based on 1 Customer Validation
Isocannflavin B (Caflanone) is a flavonoid compound. Isocannflavin B exhibits anti-tumor and anti-viral activities. Isocannflavin B induces apoptosis, autophagy and cell cycle arrest in tumor cells, and inhibits cell proliferation. Isocannflavin B inhibits HCoV-OC43. Isocannflavin B can be used in research related to cancer and COVID-19.
For research use only. We do not sell to patients.
- CAS No.: 199167-23-2
- Formula: C21H20O6
- Molecular Weight:368.38
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Isocannflavin B (1-100 μM; 24 h) inhibits the proliferation of human breast cancer T47-D cells in a concentration-dependent manner, with significant growth arrest observed starting at 1 μM, and a strong inhibitory effect at 100 μM[1].
Isocannflavin B (1-100 μM; 24 h) exerts no significant effect on the proliferation of MDA-MB-231 human breast cancer cells at concentrations ranging from 1 μM to 100 μM[1].
Isocannflavin B (25 μM; 24 h) induces autophagic cytoplasmic vacuolization in human breast cancer T47-D cells without causing chromatin condensation or nuclear fragmentation[1].
Isocannflavin B (25-100 μM; 24 h) induces cell cycle arrest in human breast cancer T47-D cells, and does not induce cell apoptosis at concentrations of 25 μM or 100 μM[1].
Isocannflavin B (10-100 μM; 0-4 h) reduces the phosphorylation level of Akt in human breast cancer T47-D cells, but exerts no effect on the phosphorylation of Akt or Erk 1/2 in human breast cancer MDA-MB-231 cells[1].
Isocannflavin B potently inhibits human coronavirus OC43 in vitro, with an EC50 of 0.42 µM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:T47-D human breast cancer cells
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Concentration:1 μM, 10 μM, 25 μM, 50 μM, 100 μM
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Incubation Time:24 h
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Result:Caused cell growth arrest starting at 1 μM, with toxic effects evident from 25 μM.
Inhibited proliferation progressively stronger with increasing concentration.
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Cell Line:T47-D human breast cancer cells
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Concentration:25 μM, 100 μM
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Incubation Time:24 h
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Result:Caused a cell cycle distribution shift at 25 μM, with 41% of cells in G0/G1, 11% in S, 48% in G2/M, and 2% in apoptosis.
Induced G0/G1 cell-cycle arrest at 100 μM, with 60% of cells in G0/G1, 12% in S, 28% in G2/M, and 0% in apoptosis.
Showed no induction of apoptotic cell death at either concentration.
Chemical Information
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CAS No. 199167-23-2
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Appearance Solid
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Molecular Weight 368.38
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Formula C21H20O6
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Color White to yellow
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SMILES
O=C1C=C(C2=CC(OC)=C(O)C=C2)OC3=C(C/C=C(C)\C)C(O)=CC(O)=C31
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Synonyms
Caflanone; FBL-03G
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 7.37 mg/mL (20.01 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.7146 mL | 13.5729 mL | 27.1459 mL | 67.8647 mL |
| 5 mM | 0.5429 mL | 2.7146 mL | 5.4292 mL | 13.5729 mL | |
| 10 mM | 0.2715 mL | 1.3573 mL | 2.7146 mL | 6.7865 mL | |
| 15 mM | 0.1810 mL | 0.9049 mL | 1.8097 mL | 4.5243 mL | |
| 20 mM | 0.1357 mL | 0.6786 mL | 1.3573 mL | 3.3932 mL |
Isocannflavin B Related Classifications
HY-N12677 Related Classifications
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