Flavonoid-induced autophagy in hormone sensitive breast cancer cells
- Fitoterapia. 2009 Sep;80(6):327-32. doi: 10.1016/j.fitote.2009.04.002.
Affiliations
- 1. Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche and Drug and Food Biotechnology Center, Università degli Studi del Piemonte Orientale "Amedeo Avogadro", Via Bovio 6, 28100 Novara, Italy.
PMID: 19371773
DOI: 10.1016/j.fitote.2009.04.002
Abstract
The activity of 8-prenylapigenin (8-PA) and its 3'-methoxylated analogue isocannflavin B (IsoB) was investigated in estrogen-dependent T47-D and estrogen-independent MDA-MB-231 human breast Cancer cell lines. 8-PA showed a biphasic effect on T47-D cell proliferation, while no significant effect was observed on MDA-MB-231 cells. Conversely, IsoB exhibited only an inhibitory effect on T47-D cell proliferation, accompanied by the appearance of an intense intracytoplasmic vacuolization of autophagic origin. Moreover, biochemical analysis showed that IsoB reduced Akt phosphorylation and p21(Cip1) expression in T47-D cells. These data show that the prenylflavone moiety is a versatile platform for the induction and modulation of bioactivity.