199167-23-2
Chemical Structure
Isocannflavin B
Synonym(s): Caflanone; FBL-03G
- CAS No.: 199167-23-2
- Formula:C21H20O6
- Molecular Weight:368.38
InChIKey: IHRNYHWGJUMPFJ-UHFFFAOYSA-N
SMILES: O=C1C=C(C2=CC(OC)=C(O)C=C2)OC3=C(C/C=C(C)\C)C(O)=CC(O)=C31
Biological Activity: Isocannflavin B (Caflanone) is an autophagy inducer that induces strong autophagic intracytoplasmic vacuolization in breast cancer cells. Isocannflavin B inhibits ACE2-mediated viral entry as well as SARS-CoV-2 PLpro and 3CLpro, and inhibits HCoV-OC43 in vitro. Isocannflavin B reduces Akt phosphorylation and p21Cip1 expression in breast cancer cells. Isocannflavin B induces tumor cell apoptosis, autophagy, and cell cycle arrest, and inhibits cell proliferation. Isocannflavin B binds to the extracellular Ig-like domain of CSF1-R as a targeting ligand. Isocannflavin B can be used for research on breast cancer, viral infection, and Parkinson's disease[1][2][3][4].
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Isocannflavin B | Isocannflavin B (Caflanone) is an autophagy inducer that induces strong autophagic intracytoplasmic vacuolization in breast cancer cells. Isocannflavin B inhibits ACE2-mediated viral entry as well as SARS-CoV-2 PLpro and 3CLpro, and inhibits HCoV-OC43 in vitro. Isocannflavin B reduces Akt phosphorylation and p21Cip1 expression in breast cancer cells. Isocannflavin B induces tumor cell apoptosis, autophagy, and cell cycle arrest, and inhibits cell proliferation. Isocannflavin B binds to the extracellular Ig-like domain of CSF1-R as a targeting ligand. Isocannflavin B can be used for research on breast cancer, viral infection, and Parkinson's disease. | |||||||||||||||||||||
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References
- [1]. Brunelli E, et al. Flavonoid-induced autophagy in hormone sensitive breast cancer cells. Fitoterapia. 2009;80(6):327-332. [Content Brief]
- [2]. Lowe H, et al. Non-Cannabinoid Metabolites of Cannabis sativa L. with Therapeutic Potential. Plants (Basel). 2021 Feb 20;10(2):400. [Content Brief]
- [3]. Holborn, Jennifer, et al. Preclinical Study of Cannflavins A and B Action Against Glioblastoma Cells. Phytomedicine Plus. 2026: 100967.
- [4]. Sun X, et al. Microglia-Specific Molecular Magnetic Resonance Imaging Probe Enables Noninvasive Separation of Parkinsonian Mice from Controls. bioRxiv [Preprint]. 2026 Jun 26:2026.06.23.734093. [Content Brief]
