Royleanone
Royleanone, a diterpenoid isolated from plants, inhibits the proliferation of cancer cells by inducing cell cycle arrest and mitochondria-mediated apoptosis, also inhibits cell migration potential, inhibits mTOR/PI3/AKT signaling pathway in LNCaP prostate cancer cells.
For research use only. We do not sell to patients.
- CAS No.: 6812-87-9
- Formula: C20H28O3
- Molecular Weight:316.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
mTOR/PI3/AKT[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | GI50 |
30.14 μM
Compound: 20
|
Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay
|
[PMID: 24210499] |
| BXPC-3 | GI50 |
51.04 μM
Compound: 20
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Cytotoxicity against human BxPC3 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human BxPC3 cells assessed as growth inhibition by WST-8 assay
|
[PMID: 24210499] |
| HL-60 | GI50 |
36.33 μM
Compound: 20
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Cytotoxicity against human HL60 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human HL60 cells assessed as growth inhibition by WST-8 assay
|
[PMID: 24210499] |
| HL-60 | IC50 |
>30 μM
Compound: 3
|
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
|
[PMID: 23865778] |
| MCF7 | IC50 |
>30 μM
Compound: 3
|
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
|
[PMID: 23865778] |
| MIA PaCa-2 | IC50 |
32.5 μM
Compound: 3
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Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay
Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay
|
[PMID: 21775156] |
| MOLT-3 | IC50 |
13.6 μM
Compound: 3
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Cytotoxicity against human MOLT3 cells after 72 hrs by MTT assay
Cytotoxicity against human MOLT3 cells after 72 hrs by MTT assay
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[PMID: 23865778] |
| MRC5 | GI50 |
45.7 μM
Compound: 20
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Cytotoxicity against human MRC5 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human MRC5 cells assessed as growth inhibition by WST-8 assay
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[PMID: 24210499] |
| PANC-1 | GI50 |
52.55 μM
Compound: 20
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Cytotoxicity against human PANC1 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human PANC1 cells assessed as growth inhibition by WST-8 assay
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[PMID: 24210499] |
| PC-3 | GI50 |
27.07 μM
Compound: 20
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Cytotoxicity against human PC3 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human PC3 cells assessed as growth inhibition by WST-8 assay
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[PMID: 24210499] |
| SK-MEL-1 | IC50 |
>30 μM
Compound: 3
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Cytotoxicity against human SK-MEL-1 cells after 72 hrs by MTT assay
Cytotoxicity against human SK-MEL-1 cells after 72 hrs by MTT assay
|
[PMID: 23865778] |
| U-937 | IC50 |
>30 μM
Compound: 3
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Cytotoxicity against human U937 cells after 72 hrs by MTT assay
Cytotoxicity against human U937 cells after 72 hrs by MTT assay
|
[PMID: 23865778] |
Chemical Information
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CAS No. 6812-87-9
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Molecular Weight 316.43
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Formula C20H28O3
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SMILES
O=C1C(C(C)C)=C(O)C(C2=C1CC[C@@]3([H])C(C)(C)CCC[C@]23C)=O
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Synonyms
NSC 122417
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Wu X, et al. Royleanone diterpenoid exhibits potent anticancer effects in LNCaP human prostate carcinoma cells by inducing mitochondrial mediated apoptosis, cell cycle arrest, suppression of cell migration and downregulation of mTOR/PI3K/AKT signalling pathway. J BUON. 2018 Jul-Aug;23(4):1055-1060. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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