2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. EGFR CDK Cytochrome P450
  4. IMP-Zn

IMP-Zn is a pyrazole-hydrazone Schiff base zinc (II) complex. IMP-Zn exhibits significant antiproliferative activity against human colorectal cancer cells and induces cell cycle arrest. IMP-Zn shows stronger binding affinity than its free ligand IMP towards three cancer-related protein targets: EGFR kinase 1M17, cytochrome P450 3RUK, and CDK inhibitor 6GUE. IMP-Zn can be used in studies related to colorectal cancer.

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IMP-Zn

IMP-Zn Chemical Structure

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IMP-Zn Related Antibodies

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

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Description

IMP-Zn is a pyrazole-hydrazone Schiff base zinc (II) complex. IMP-Zn exhibits significant antiproliferative activity against human colorectal cancer cells and induces cell cycle arrest. IMP-Zn shows stronger binding affinity than its free ligand IMP towards three cancer-related protein targets: EGFR kinase 1M17, cytochrome P450 3RUK, and CDK inhibitor 6GUE. IMP-Zn can be used in studies related to colorectal cancer[1].

In Vitro

IMP-Zn (10, 20, 30, 40, 50 μM; 24, 48, 72 h for HCT116, 48 h for HEK293) potently reduces viability of human colorectal carcinoma HCT116 cells with IC50 values of 28.62 μM (24 h), 24.56 μM (48 h), and 24.28 μM (72 h), while showing no cytotoxicity toward normal HEK293 cells at concentrations up to 50 μM after 48 h[1].
IMP-Zn (10, 20, 24.56 μM; 48 h treatment, followed by 10-day colony formation period) dose-dependently suppresses clonogenic growth of human colorectal carcinoma HCT116 cells, reducing both colony number and size[1].
IMP-Zn (24.56 μM; 48 h treatment) induces SubG0 phase accumulation in human colorectal carcinoma HCT116 cells, indicating apoptosis-associated cell death[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IMP-Zn Related Antibodies

Cell Viability Assay[1]

Cell Line: human colorectal carcinoma HCT116 cells, normal human embryonic kidney HEK293 cells
Concentration: 10, 20, 30, 40, 50 μM (HCT116 cells); 10, 20, 30, 40, 50 μM (HEK293 cells)
Incubation Time: 24, 48, 72 h (HCT116 cells); 48 h (HEK293 cells)
Result: Reduced HCT116 cell viability in a time- and dose-dependent manner, with IC50 values of 28.62 μM (24 h), 24.56 μM (48 h), and 24.28 μM (72 h).
Showed no significant effect on HEK293 cell viability at concentrations up to 50 μM after 48 h.

Cell Cycle Analysis[1]

Cell Line: human colorectal carcinoma HCT116 cells
Concentration: 24.56 μM
Incubation Time: 48 h
Result: Increased the percentage of HCT116 cells in the SubG0 phase to 20.51% compared to 5.86% in control cells.
Molecular Weight

441.62

Formula

C17H15Cl2N5OZn
SMILES

CC1=C(C(N2)=O[Zn]3(Cl)(Cl)[N]2=CC4=[N]3C=CC=C4)C=NN1C5=CC=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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IMP-Zn Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IMP-ZnEGFRCDKCytochrome P450Epidermal growth factor receptorErbB-1HER1Cyclin dependent kinaseCYPscytochrome P450apoptosisnormal human embryonic kidney cellsHEK293colorectal carcinomaepidermal growth factor receptorcyclin-dependent kinase inhibitorHCT116SubG0 phasecolorectal carcinoma cellsInhibitorinhibitorinhibit

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