2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK2-IN-57

CDK2-IN-57 is a selective Cdk2/CycE inhibitor with an IC50 of 2.8 nM. CDK2-IN-57 inhibits Cdk1/2 kinase activity, blocks cell cycle progression, induces G0-phase cell cycle arrest, and prevents S-phase entry. CDK2-IN-57 can be used for the research of colon carcinoma.

For research use only. We do not sell to patients.

CDK2-IN-57

CDK2-IN-57 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

CDK2-IN-57 Related Antibodies

Top Publications Citing Use of Products

View All CDK Isoform Specific Products:

View All Isoforms
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CDK2-IN-57 is a selective Cdk2/CycE inhibitor with an IC50 of 2.8 nM. CDK2-IN-57 inhibits Cdk1/2 kinase activity, blocks cell cycle progression, induces G0-phase cell cycle arrest, and prevents S-phase entry. CDK2-IN-57 can be used for the research of colon carcinoma[1].

IC50 & Target[1]

CDK2/Cyc E

2.8 nM (IC50)

In Vitro

CDK2-IN-57 (Compound 22) potently inhibits the purified Cdk2/CycE complex with an IC50 of 2.8 nM[1].
CDK2-IN-57 (20 nM-100 μM; 48 h) induces dose-responsive cell cycle arrest at G0 and reduced viability in HCT-116 colon cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CDK2-IN-57 Related Antibodies

Cell Cycle Analysis[1]

Cell Line: HCT-116 colon cancer cells
Concentration: 20 nM; 50 nM; 100 nM; 200 nM; 390 nM; 780 nM; 1.56 μM; 3.13 μM; 6.25 μM; 12.5 μM; 25 μM; 50 μM; 100 μM
Incubation Time: 48 h
Result: Reduced cell number of cells positive for Edu and pHH3 in a dose-dependent manner.
Induces dose-responsive cell cycle arrest at G0 and reduced viability.
Molecular Weight

414.50

Formula

C22H30N4O4
SMILES

O=C(CC1=CC=C(C=C1)OC)NC2=NNC([C@H]3CC[C@@H](OC(N(C)C(C)C)=O)C3)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

CDK2-IN-57 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK2-IN-57CDKCyclin dependent kinasephospho-Histone H3Cdk1/2 kinaseCdk2/CycE complexS-phasecancer cell viabilityG0-phase cell cycle arrestcell cycle progressioncolon carcinomaHCT-116 colon cancer cellsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
CDK2-IN-57
Cat. No.:
HY-183146
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.