CHK1-IN-12
CHK1-IN-12 (Compound example 1-5) is an orally active and highly selective checkpoint kinase 1 (CHK1) inhibitor with in vitro enzyme IC50≤10 nM and cellular IC50≤50 nM. CHK1-IN-12 inhibits the phosphorylation activity of CHK1 kinase to block the DNA damage response pathway, inducing tumor cell cycle arrest and apoptosis. CHK1-IN-12 is promising for research of cancers.
For research use only. We do not sell to patients.
- CAS No.: 2871056-82-3
- Formula: C19H19N7O2
- Molecular Weight:377.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Chk1 |
Chemical Information
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CAS No. 2871056-82-3
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Molecular Weight 377.40
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Formula C19H19N7O2
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SMILES
COC1=CC=CC(O[C@@H]2C[C@H](C2)N)=C1C3=CC(NC4=NC=C(C#N)N=C4)=NN3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CHK1-IN-12 Related Classifications
HY-171785 Related Classifications
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