2871056-82-3
2871056-82-3
Chemical Structure
CHK1-IN-12
- CAS No.: 2871056-82-3
- Formula:C19H19N7O2
- Molecular Weight:377.40
SMILES: COC1=CC=CC(O[C@@H]2C[C@H](C2)N)=C1C3=CC(NC4=NC=C(C#N)N=C4)=NN3
Biological Activity: CHK1-IN-12 (Compound example 1-5) is an orally active and highly selective checkpoint kinase 1 (CHK1) inhibitor with in vitro enzyme IC50≤10 nM and cellular IC50≤50 nM. CHK1-IN-12 inhibits the phosphorylation activity of CHK1 kinase to block the DNA damage response pathway, inducing tumor cell cycle arrest and apoptosis. CHK1-IN-12 is promising for research of cancers[1].
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CHK1-IN-12 | CHK1-IN-12 (Compound example 1-5) is an orally active and highly selective checkpoint kinase 1 (CHK1) inhibitor with in vitro enzyme IC50≤10 nM and cellular IC50≤50 nM. CHK1-IN-12 inhibits the phosphorylation activity of CHK1 kinase to block the DNA damage response pathway, inducing tumor cell cycle arrest and apoptosis. CHK1-IN-12 is promising for research of cancers. | |||||||||||||||||||||
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